7α-[(1R)-1-hydroxy-1-(3,4-dimethoxyphenyl)ethyl]epi-podophyllotoxin

Base Information

• Chemical Name: 7α-[(1R)-1-hydroxy-1-(3,4-dimethoxyphenyl)ethyl]epi-podophyllotoxin
• CAS No.: 1391928-22-5
• Molecular Formula: C₃₂H₃₄O₁₁
• Molecular Weight: 594.615
• Mol file: 1391928-22-5.mol

Synonyms:7α-[(1R)-1-hydroxy-1-(3,4-dimethoxyphenyl)ethyl]epi-podophyllotoxin

Chemical Property of 7α-[(1R)-1-hydroxy-1-(3,4-dimethoxyphenyl)ethyl]epi-podophyllotoxin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7α-[(1R)-1-hydroxy-1-(3,4-dimethoxyphenyl)ethyl]epi-podophyllotoxin

There total 1 articles about 7α-[(1R)-1-hydroxy-1-(3,4-dimethoxyphenyl)ethyl]epi-podophyllotoxin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

1-(3,4-dimethoxyphenyl)ethanone (1131-62-0) + podophyllotoxone (477-48-5,477-49-6,55515-07-6,60660-51-7,64550-42-1,64937-82-2,86594-36-7,130322-38-2) → 7α-[(1R)-1-hydroxy-1-(3,4-dimethoxyphenyl)ethyl]epi-podophyllotoxin (1391928-22-5) + deoxypodophyllotoxin (477-51-0,6258-33-9,17187-81-4,17301-90-5,19186-35-7,24150-39-8,31892-96-3,55568-81-5,64550-41-0,69222-20-4,75171-57-2,83023-41-0,100348-38-7) + podofilox (518-28-5)

Guidance literature:

With titanium tetrachloride; zinc; In tetrahydrofuran; at -20 - -10 ℃; for 4h; Inert atmosphere;

DOI:10.1021/jm2017573

upstream raw materials:

1-(3,4-dimethoxyphenyl)ethanone

podophyllotoxone