benzoic acid, 2-<<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)pentyl>thio>-, <3aS-(3aα,4β,6aα)>-

Base Information

• Chemical Name: benzoic acid, 2-<<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)pentyl>thio>-, <3aS-(3aα,4β,6aα)>-
• CAS No.: 153805-34-6
• Molecular Formula: C₁₇H₂₂N₂O₃S₂
• Molecular Weight: 366.505
• Mol file: 153805-34-6.mol

Synonyms:benzoic acid, 2-<<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)pentyl>thio>-, <3aS-(3aα,4β,6aα)>-

Chemical Property of benzoic acid, 2-<<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)pentyl>thio>-, <3aS-(3aα,4β,6aα)>-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzoic acid, 2-<<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)pentyl>thio>-, <3aS-(3aα,4β,6aα)>-

There total 4 articles about benzoic acid, 2-<<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)pentyl>thio>-, <3aS-(3aα,4β,6aα)>- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

benzoic acid methyl ester, 2-<<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)pentyl>thio>-, <3aS-(3aα,4β,6aα)>- (153805-33-5) → benzoic acid, 2-<<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)pentyl>thio>-, <3aS-(3aα,4β,6aα)>- (153805-34-6)

Guidance literature:

With sodium hydroxide; In methanol; dichloromethane; at 60 ℃; for 14h;

DOI:10.1021/jm00028a013

Reference yield:

biotin N-Hydroxysuccinimide ester (35013-72-0) → benzoic acid, 2-<<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)pentyl>thio>-, <3aS-(3aα,4β,6aα)>- (153805-34-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 67 percent / NaBH₄ / hexamethylphosphoric acid triamide; tetrahydrofuran / 4 h / Ambient temperature

2: 90 percent / pyridine; CH₂Cl₂ / 10 h / Ambient temperature

3: 90 percent / 1.) K₂CO₃ / dimethylformamide / 18 h / Ambient temperature

4: 92 percent / 1N aq. NaOH / methanol; CH₂Cl₂ / 14 h / 60 °C

With sodium hydroxide; sodium tetrahydroborate; potassium carbonate; In tetrahydrofuran; pyridine; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00028a013

Reference yield:

1H-thieno<3,4-d>imidazol-2(3H)-one, tetrahydro-4-<5-(methylsulfonyl)pentyl>-, <3aS-(3aα,4β,6aα)>- (146395-18-8) → benzoic acid, 2-<<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)pentyl>thio>-, <3aS-(3aα,4β,6aα)>- (153805-34-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / 1.) K₂CO₃ / dimethylformamide / 18 h / Ambient temperature

2: 92 percent / 1N aq. NaOH / methanol; CH₂Cl₂ / 14 h / 60 °C

With sodium hydroxide; potassium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00028a013

upstream raw materials:

benzoic acid methyl ester, 2-<<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)pentyl>thio>-, <3aS-(3aα,4β,6aα)>-

biotin N-Hydroxysuccinimide ester

1H-thieno<3,4-d>imidazol-2(3H)-one, tetrahydro-4-<5-(methylsulfonyl)pentyl>-, <3aS-(3aα,4β,6aα)>-

1H-thieno<3,4-d>imidazol-2(3H)-one, tetrahydro-4-(5-hydroxypentyl)-, <3aS-(3aα,4β,6aα)>-