N-hydroxy-2-(2-phenyl-1,3-dioxolan-2-yl)ethanimidamide

Base Information

• Chemical Name: N-hydroxy-2-(2-phenyl-1,3-dioxolan-2-yl)ethanimidamide
• CAS No.: 1311369-43-3
• Molecular Formula: C₁₁H₁₄N₂O₃
• Molecular Weight: 222.244
• Mol file: 1311369-43-3.mol

Synonyms:N-hydroxy-2-(2-phenyl-1,3-dioxolan-2-yl)ethanimidamide

Chemical Property of N-hydroxy-2-(2-phenyl-1,3-dioxolan-2-yl)ethanimidamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-hydroxy-2-(2-phenyl-1,3-dioxolan-2-yl)ethanimidamide

There total 2 articles about N-hydroxy-2-(2-phenyl-1,3-dioxolan-2-yl)ethanimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(2-phenyl-[1,3]dioxolan-2-yl)-acetonitrile (5738-30-7) → N-hydroxy-2-(2-phenyl-1,3-dioxolan-2-yl)ethanimidamide (1311369-43-3)

Guidance literature:

With hydroxylamine hydrochloride; sodium hydroxide; In methanol; at 0 - 90 ℃; for 16h;

Reference yield:

Benzoylacetonitrile (614-16-4) → N-hydroxy-2-(2-phenyl-1,3-dioxolan-2-yl)ethanimidamide (1311369-43-3)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / toluene / 14 h / 150 °C

2: hydroxylamine hydrochloride; sodium hydroxide / methanol / 16 h / 0 - 90 °C

With hydroxylamine hydrochloride; toluene-4-sulfonic acid; sodium hydroxide; In methanol; toluene;

Reference yield: 34.0%

N-hydroxy-2-(2-phenyl-1,3-dioxolan-2-yl)ethanimidamide (1311369-43-3) → 3-amino-5-phenylisoxazole (6455-31-8)

Guidance literature:

With hydrogenchloride; In ethanol; water; at 90 ℃; for 2h; pH=1;

upstream raw materials:

Benzoylacetonitrile

(2-phenyl-[1,3]dioxolan-2-yl)-acetonitrile

Downstream raw materials:

3-amino-5-phenylisoxazole