N-(5-(2-((2-(4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl)hexyl)amino)-1-hydroxyethyl)-2-hydroxyphenyl)formamide

Base Information

Chemical Name:N-(5-(2-((2-(4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl)hexyl)amino)-1-hydroxyethyl)-2-hydroxyphenyl)formamide
CAS No.:1361398-81-3
Molecular Formula:C₃₁H₄₂N₄O₆
Molecular Weight:566.698
Hs Code.:

Synonyms:N-(5-(2-((2-(4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl)hexyl)amino)-1-hydroxyethyl)-2-hydroxyphenyl)formamide

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Chemical Property of N-(5-(2-((2-(4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl)hexyl)amino)-1-hydroxyethyl)-2-hydroxyphenyl)formamide

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Technology Process of N-(5-(2-((2-(4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl)hexyl)amino)-1-hydroxyethyl)-2-hydroxyphenyl)formamide

There total 13 articles about N-(5-(2-((2-(4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl)hexyl)amino)-1-hydroxyethyl)-2-hydroxyphenyl)formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1361398-77-7
N-(5-(2-(benzyl(2-(4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl)hexyl)amino)-1-hydroxyethyl)-2-(benzyloxy)phenyl)formamide

: 1361398-81-3
N-(5-(2-((2-(4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl)hexyl)amino)-1-hydroxyethyl)-2-hydroxyphenyl)formamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; under 20686.5 Torr;
DOI:10.1016/j.bmcl.2012.01.013

Reference yield:

: N-(2-(benzyloxy)-5-(2-bromo-1-hydroxyethyl)phenyl)formamide

: 1361398-81-3
N-(5-(2-((2-(4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl)hexyl)amino)-1-hydroxyethyl)-2-hydroxyphenyl)formamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / tetrahydrofuran; methanol

2: 4 h / 120 °C / Neat (no solvent)

3: palladium 10% on activated carbon; hydrogen / methanol / 20686.5 Torr

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2012.01.013

Reference yield:

: 2-(2-bromohexyl)-4-(3,4-dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydrophthalazin-1(2H)-one

: 1361398-81-3
N-(5-(2-((2-(4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl)hexyl)amino)-1-hydroxyethyl)-2-hydroxyphenyl)formamide

Guidance literature:: Multi-step reaction with 3 steps

1: 3 h / 20 °C

2: 4 h / 120 °C / Neat (no solvent)

3: palladium 10% on activated carbon; hydrogen / methanol / 20686.5 Torr

With palladium 10% on activated carbon; hydrogen; In methanol;
DOI:10.1016/j.bmcl.2012.01.013