tert-Butyl-((2S,4R)-2-{2-cyclopentyl-6-[3-(4-fluoro-phenoxy)-propyl]-phenoxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-diphenyl-silane

Base Information

Chemical Name:tert-Butyl-((2S,4R)-2-{2-cyclopentyl-6-[3-(4-fluoro-phenoxy)-propyl]-phenoxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-diphenyl-silane
CAS No.:110723-84-7
Molecular Formula:C₄₃H₅₃FO₅Si
Molecular Weight:696.975
Hs Code.:

Synonyms:tert-Butyl-((2S,4R)-2-{2-cyclopentyl-6-[3-(4-fluoro-phenoxy)-propyl]-phenoxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-diphenyl-silane

Suppliers and Price of tert-Butyl-((2S,4R)-2-{2-cyclopentyl-6-[3-(4-fluoro-phenoxy)-propyl]-phenoxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-diphenyl-silane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-Butyl-((2S,4R)-2-{2-cyclopentyl-6-[3-(4-fluoro-phenoxy)-propyl]-phenoxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-diphenyl-silane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-Butyl-((2S,4R)-2-{2-cyclopentyl-6-[3-(4-fluoro-phenoxy)-propyl]-phenoxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-diphenyl-silane

There total 12 articles about tert-Butyl-((2S,4R)-2-{2-cyclopentyl-6-[3-(4-fluoro-phenoxy)-propyl]-phenoxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 371-41-5
4-Fluorophenol

: 110723-84-7
tert-Butyl-((2S,4R)-2-{2-cyclopentyl-6-[3-(4-fluoro-phenoxy)-propyl]-phenoxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-diphenyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1: dimethylsulfoxide / 4 h / 60 °C

2: H₂, conc. HCl / 10percent Pd/C / acetic acid / 0.33 h / 25 °C / 750.06 Torr

3: 94 percent / H₂ / 10percent Pd/C / ethyl acetate / 12 h / 750.06 Torr

4: K₂CO₃, hydroquinone / dimethylsulfoxide / 3 h / 70 °C

With hydrogenchloride; hydrogen; potassium carbonate; hydroquinone; palladium on activated charcoal; In acetic acid; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/jm00114a004

Reference yield:

: 2-Allyl-4-chloro-6-cyclopentyl-phenol

: 110723-84-7
tert-Butyl-((2S,4R)-2-{2-cyclopentyl-6-[3-(4-fluoro-phenoxy)-propyl]-phenoxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-diphenyl-silane

Guidance literature:: Multi-step reaction with 8 steps

1: K₂CO₃ / dimethylformamide / 8 h / 70 - 75 °C

2: 1.) 9-BBN, 2.) 2N aq. NaOH, H₂O₂ / 1.) THF, a) 25 deg C, 30 min, b) reflux, 90 min, 2.) THF, reflux, 1 h

3: pyridine / CH₂Cl₂ / 6 h / 20 °C

4: NaI / acetone / 4 h / Heating

5: dimethylsulfoxide / 4 h / 60 °C

6: H₂, conc. HCl / 10percent Pd/C / acetic acid / 0.33 h / 25 °C / 750.06 Torr

7: 94 percent / H₂ / 10percent Pd/C / ethyl acetate / 12 h / 750.06 Torr

8: K₂CO₃, hydroquinone / dimethylsulfoxide / 3 h / 70 °C

With pyridine; hydrogenchloride; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; hydrogen; dihydrogen peroxide; potassium carbonate; hydroquinone; sodium iodide; palladium on activated charcoal; In dichloromethane; acetic acid; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00114a004

Reference yield:

: 1-Allyloxy-4-chloro-2-cyclopentyl-benzene

: 110723-84-7
tert-Butyl-((2S,4R)-2-{2-cyclopentyl-6-[3-(4-fluoro-phenoxy)-propyl]-phenoxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-diphenyl-silane

Guidance literature:: Multi-step reaction with 9 steps

1: N,N-dimethylaniline / bis-(2-methoxy-ethyl) ether / 10 h / 160 °C

2: K₂CO₃ / dimethylformamide / 8 h / 70 - 75 °C

3: 1.) 9-BBN, 2.) 2N aq. NaOH, H₂O₂ / 1.) THF, a) 25 deg C, 30 min, b) reflux, 90 min, 2.) THF, reflux, 1 h

4: pyridine / CH₂Cl₂ / 6 h / 20 °C

5: NaI / acetone / 4 h / Heating

6: dimethylsulfoxide / 4 h / 60 °C

7: H₂, conc. HCl / 10percent Pd/C / acetic acid / 0.33 h / 25 °C / 750.06 Torr

8: 94 percent / H₂ / 10percent Pd/C / ethyl acetate / 12 h / 750.06 Torr

9: K₂CO₃, hydroquinone / dimethylsulfoxide / 3 h / 70 °C

With pyridine; hydrogenchloride; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; hydrogen; dihydrogen peroxide; potassium carbonate; N,N-dimethyl-aniline; hydroquinone; sodium iodide; palladium on activated charcoal; In dichloromethane; diethylene glycol dimethyl ether; acetic acid; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00114a004