(S)-N-benzyloxycarbonyl-O-(4-methoxybenzyl)-3-iodotyrosine tert-butyl ester

Base Information

Chemical Name:(S)-N-benzyloxycarbonyl-O-(4-methoxybenzyl)-3-iodotyrosine tert-butyl ester
CAS No.:935846-57-4
Molecular Formula:C₂₉H₃₂INO₆
Molecular Weight:617.481
Hs Code.:

Synonyms:(S)-N-benzyloxycarbonyl-O-(4-methoxybenzyl)-3-iodotyrosine tert-butyl ester

Suppliers and Price of (S)-N-benzyloxycarbonyl-O-(4-methoxybenzyl)-3-iodotyrosine tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-N-benzyloxycarbonyl-O-(4-methoxybenzyl)-3-iodotyrosine tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-N-benzyloxycarbonyl-O-(4-methoxybenzyl)-3-iodotyrosine tert-butyl ester

There total 1 articles about (S)-N-benzyloxycarbonyl-O-(4-methoxybenzyl)-3-iodotyrosine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 824-94-2
p-methoxybenzyl chloride

: 870456-12-5
(S)-N-benzyloxycarbonyl-3-iodotyrosine tert-butyl ester

: 935846-57-4
(S)-N-benzyloxycarbonyl-O-(4-methoxybenzyl)-3-iodotyrosine tert-butyl ester

Guidance literature:: With 18-crown-6 ether; tetra-(n-butyl)ammonium iodide; potassium carbonate; In acetone; for 12h; Heating;
DOI:10.1021/jo062627r

Reference yield: 70.0%

: 935846-57-4
(S)-N-benzyloxycarbonyl-O-(4-methoxybenzyl)-3-iodotyrosine tert-butyl ester

: 25015-63-8
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

: 935846-53-0
(S)-N-benzyloxycarbonyl-O-(4-methoxybenzyl)-3-[4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl]tyrosine tert-butyl ester

Guidance literature:: With triethylamine; CyJohnPhos; palladium diacetate; In 1,4-dioxane; at 85 ℃; for 0.5h;
DOI:10.1021/jo062627r

Reference yield:

: 935846-57-4
(S)-N-benzyloxycarbonyl-O-(4-methoxybenzyl)-3-iodotyrosine tert-butyl ester

: 10-allyl 4b-ethyl 6-(2-benzyloxycarbonylamino-2-tert-butoxycarbonylethyl)-10-bromo-9a,10-dihydro-10-aza-9-oxaindeno[1,2-a]indene-4b,10-dicarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 70 percent / triethylamine; 2-(dicyclohexylphosphino)biphenyl / palladium(II) acetate / dioxane / 0.5 h / 85 °C

2.1: 40 percent / aq. potassium carbonate / PdCl₂(dppf)*CH₂Cl₂ / 1,2-dimethoxy-ethane / 45 h / 35 °C

3.1: tert-butyl hypochlorite / CH₂Cl₂ / 8 h / 20 °C

3.2: 68 percent / acetyl chloride / ethanol; CH₂Cl₂

4.1: sodium hydride / tetrahydrofuran; CH₂Cl₂; various solvent(s) / 0 - 20 °C

4.2: 63 percent / 4-(dimethylamino)pyridine / tetrahydrofuran; CH₂Cl₂; various solvent(s) / 2 h

5.1: sodium borohydride / tetrahydrofuran; methanol / 0.5 h / 0 °C

6.1: 10 mg / triethylamine; methanesulfonic anhydride / CH₂Cl₂ / 52 h

With sodium tetrahydroborate; tert-butylhypochlorite; sodium hydride; potassium carbonate; triethylamine; CyJohnPhos; Methanesulfonic anhydride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/jo062627r