(-)-(S)-benzyl 2-((4-methoxyquinolin-8-yl)carbamoyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(-)-(S)-benzyl 2-((4-methoxyquinolin-8-yl)carbamoyl)pyrrolidine-1-carboxylate
CAS No.:1514927-36-6
Molecular Formula:C₂₃H₂₃N₃O₄
Molecular Weight:405.453
Hs Code.:

Synonyms:(-)-(S)-benzyl 2-((4-methoxyquinolin-8-yl)carbamoyl)pyrrolidine-1-carboxylate

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Chemical Property of (-)-(S)-benzyl 2-((4-methoxyquinolin-8-yl)carbamoyl)pyrrolidine-1-carboxylate

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Technology Process of (-)-(S)-benzyl 2-((4-methoxyquinolin-8-yl)carbamoyl)pyrrolidine-1-carboxylate

There total 6 articles about (-)-(S)-benzyl 2-((4-methoxyquinolin-8-yl)carbamoyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 30465-68-0
5-methoxy-8-aminoquinoline

: 1148-11-4
N-Benzyloxycarbonyl-L-proline

: 1514927-36-6
(-)-(S)-benzyl 2-((4-methoxyquinolin-8-yl)carbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/ol403364k

Reference yield: 49.0%

: 36020-53-8
6-methoxy-8-nitroquinoline

: 1148-11-4
N-Benzyloxycarbonyl-L-proline

: 1514927-36-6
(-)-(S)-benzyl 2-((4-methoxyquinolin-8-yl)carbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 48h; Inert atmosphere;
DOI:10.1021/ol502511g

Reference yield:

: 6942-98-9
5-chloro-8-nitroquinoline

: 1514927-36-6
(-)-(S)-benzyl 2-((4-methoxyquinolin-8-yl)carbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium / 3 h / Reflux; Inert atmosphere

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 48 h / 20 °C / Inert atmosphere

With sodium; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1021/ol502511g