[5-(2,6-dimethyl-phenyl)-[1,2,4]triazin-3-yl]-(5-methoxy-benzothiazol-2-ylmethyl)-amine

Base Information

Chemical Name:[5-(2,6-dimethyl-phenyl)-[1,2,4]triazin-3-yl]-(5-methoxy-benzothiazol-2-ylmethyl)-amine
CAS No.:1203604-73-2
Molecular Formula:C₂₀H₁₉N₅OS
Molecular Weight:377.47
Hs Code.:

Synonyms:[5-(2,6-dimethyl-phenyl)-[1,2,4]triazin-3-yl]-(5-methoxy-benzothiazol-2-ylmethyl)-amine

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Chemical Property of [5-(2,6-dimethyl-phenyl)-[1,2,4]triazin-3-yl]-(5-methoxy-benzothiazol-2-ylmethyl)-amine

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Technology Process of [5-(2,6-dimethyl-phenyl)-[1,2,4]triazin-3-yl]-(5-methoxy-benzothiazol-2-ylmethyl)-amine

There total 9 articles about [5-(2,6-dimethyl-phenyl)-[1,2,4]triazin-3-yl]-(5-methoxy-benzothiazol-2-ylmethyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1203604-04-9
5-(4-Bromo-2,6-dimethylphenyl)-N-[(5-methoxy-1,3-benzothiazol-2-yl)methyl]-1,2,4-triazin-3-amine

: 1203604-73-2
[5-(2,6-dimethyl-phenyl)-[1,2,4]triazin-3-yl]-(5-methoxy-benzothiazol-2-ylmethyl)-amine

Guidance literature:: With triethylsilane; cesium fluoride; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; In 1,4-dioxane; at 50 ℃; for 72h; Inert atmosphere;

Reference yield:

: 854059-90-8
5-methoxybenzothiazole-2-carboxaldehyde

: 1203604-73-2
[5-(2,6-dimethyl-phenyl)-[1,2,4]triazin-3-yl]-(5-methoxy-benzothiazol-2-ylmethyl)-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium methylate; hydroxylamine hydrochloride / ethanol / 20 °C / Inert atmosphere

2.1: acetic acid; zinc / 3 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 50 - 85 °C / Inert atmosphere

4.1: triethylsilane; cesium fluoride; PdCl₂(dppf)2*CHCl₃ / 1,4-dioxane / 72 h / 50 °C / Inert atmosphere

With triethylsilane; PdCl₂(dppf)2*CHCl₃; hydroxylamine hydrochloride; sodium methylate; acetic acid; N-ethyl-N,N-diisopropylamine; cesium fluoride; zinc; In 1,4-dioxane; ethanol; acetonitrile;
DOI:10.1021/jm301499r

Reference yield:

: 1203605-11-1
5-methoxy-1,3-benzothiazole-2-carbaldehyde oxime

: 1203604-73-2
[5-(2,6-dimethyl-phenyl)-[1,2,4]triazin-3-yl]-(5-methoxy-benzothiazol-2-ylmethyl)-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; zinc / 3 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 50 - 85 °C / Inert atmosphere

3.1: triethylsilane; cesium fluoride; PdCl₂(dppf)2*CHCl₃ / 1,4-dioxane / 72 h / 50 °C / Inert atmosphere

With triethylsilane; PdCl₂(dppf)2*CHCl₃; acetic acid; N-ethyl-N,N-diisopropylamine; cesium fluoride; zinc; In 1,4-dioxane; acetonitrile;
DOI:10.1021/jm301499r