Technology Process of benzyl-(9-methyl-9H-xanthen-9-ylmethyl)-amine
There total 5 articles about benzyl-(9-methyl-9H-xanthen-9-ylmethyl)-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
9-methyl-9H-xanthene-9-carboxylic acid benzylamide;
With
dimethylsulfide borane complex;
In
tetrahydrofuran;
at 150 ℃;
for 0.25h;
Microwave irradiation;
With
hydrogenchloride; water;
In
tetrahydrofuran;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydroxide; water / 1,4-dioxane / 60 °C
2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.08 h / 0 °C
2.2: 20 °C
3.1: dimethylsulfide borane complex / tetrahydrofuran / 0.25 h / 150 °C / Microwave irradiation
3.2: 20 °C
With
sodium hydroxide; dimethylsulfide borane complex; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water;
In
tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C
2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C
2.2: 0.5 h / -78 °C
2.3: 1 h / -78 °C
3.1: sodium hydroxide; water / 1,4-dioxane / 60 °C
4.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.08 h / 0 °C
4.2: 20 °C
5.1: dimethylsulfide borane complex / tetrahydrofuran / 0.25 h / 150 °C / Microwave irradiation
5.2: 20 °C
With
sodium hydroxide; dimethylsulfide borane complex; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; caesium carbonate; lithium diisopropyl amide;
In
tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
