4-N-(11-fluoroundecanyl)-3',5'-di-O-benzoyl-2'-deoxy-2',2'-difluorocytidine

Base Information

Chemical Name:4-N-(11-fluoroundecanyl)-3',5'-di-O-benzoyl-2'-deoxy-2',2'-difluorocytidine
CAS No.:1519060-72-0
Molecular Formula:C₃₄H₄₀F₃N₃O₆
Molecular Weight:643.703
Hs Code.:

Synonyms:4-N-(11-fluoroundecanyl)-3',5'-di-O-benzoyl-2'-deoxy-2',2'-difluorocytidine

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Chemical Property of 4-N-(11-fluoroundecanyl)-3',5'-di-O-benzoyl-2'-deoxy-2',2'-difluorocytidine

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Technology Process of 4-N-(11-fluoroundecanyl)-3',5'-di-O-benzoyl-2'-deoxy-2',2'-difluorocytidine

There total 13 articles about 4-N-(11-fluoroundecanyl)-3',5'-di-O-benzoyl-2'-deoxy-2',2'-difluorocytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1519060-71-9
4-N-(11-hydroxyundecanyl)-3',5'-di-O-benzoyl-2'-deoxy-2',2'-difluorocytidine

: 1519060-72-0
4-N-(11-fluoroundecanyl)-3',5'-di-O-benzoyl-2'-deoxy-2',2'-difluorocytidine

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at -78 - 20 ℃; for 3.5h; Inert atmosphere;
DOI:10.1021/jm401586a

Reference yield:

: 1519060-74-2
4-N-[11-(methanesulfonyloxy)undecanyl]-3',5'-di-O-benzoyl-2'-deoxy-2',2'-difluorocytidine

: 1519060-72-0
4-N-(11-fluoroundecanyl)-3',5'-di-O-benzoyl-2'-deoxy-2',2'-difluorocytidine

Guidance literature:: With potassium fluoride; potassium carbonate; [2.2.2]cryptande; In acetonitrile; at 110 ℃; for 0.3h; Inert atmosphere; Sealed tube;
DOI:10.1021/jm401586a

Reference yield:

: 1519060-68-4
N-(1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-4-methylbenzenesulfonamide

: 1519060-72-0
4-N-(11-fluoroundecanyl)-3',5'-di-O-benzoyl-2'-deoxy-2',2'-difluorocytidine

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / 1,4-dioxane / 96 h / 75 °C / Sealed tube; Inert atmosphere

2: dmap; 2,6-dimethylpyridine / dichloromethane / 20 h / 35 °C / Inert atmosphere

3: ammonium cerium (IV) nitrate / 72 h / 20 °C / Inert atmosphere

4: diethylamino-sulfur trifluoride / dichloromethane / 3.5 h / -78 - 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; dmap; ammonium cerium (IV) nitrate; diethylamino-sulfur trifluoride; triethylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm401586a