1-[(4-fluoro-2-trifluoromethyl-benzyl)-piperidin-4-yl-amino]-2-methyl-propan-2-ol

Base Information

Chemical Name:1-[(4-fluoro-2-trifluoromethyl-benzyl)-piperidin-4-yl-amino]-2-methyl-propan-2-ol
CAS No.:710981-72-9
Molecular Formula:C₁₇H₂₄F₄N₂O
Molecular Weight:348.384
Hs Code.:

Synonyms:1-[(4-fluoro-2-trifluoromethyl-benzyl)-piperidin-4-yl-amino]-2-methyl-propan-2-ol

Suppliers and Price of 1-[(4-fluoro-2-trifluoromethyl-benzyl)-piperidin-4-yl-amino]-2-methyl-propan-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[(4-fluoro-2-trifluoromethyl-benzyl)-piperidin-4-yl-amino]-2-methyl-propan-2-ol

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Technology Process of 1-[(4-fluoro-2-trifluoromethyl-benzyl)-piperidin-4-yl-amino]-2-methyl-propan-2-ol

There total 2 articles about 1-[(4-fluoro-2-trifluoromethyl-benzyl)-piperidin-4-yl-amino]-2-methyl-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 4-[(4-fluoro-2-trifluoromethyl-benzyl)-(2-hydroxy-2-methyl-propyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester

: 710981-72-9
1-[(4-fluoro-2-trifluoromethyl-benzyl)-piperidin-4-yl-amino]-2-methyl-propan-2-ol

Guidance literature:: With trifluoroacetic acid; In dichloromethane; methoxybenzene;
DOI:10.1016/j.bmcl.2006.02.008

Reference yield:

: 710981-79-6
4-(4-fluoro-2-trifluoromethyl-benzylamino)-piperidine-l-carboxylic acid tert-butyl ester

: 710981-72-9
1-[(4-fluoro-2-trifluoromethyl-benzyl)-piperidin-4-yl-amino]-2-methyl-propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / LiClO₄ / methanol / 65 °C

2: 92 percent / TFA / methoxybenzene; CH₂Cl₂

With lithium perchlorate; trifluoroacetic acid; In methanol; dichloromethane; methoxybenzene;
DOI:10.1016/j.bmcl.2006.02.008