(2S,R_S)-2-anilino-2-[4-(methoxyphenyl)]ethyl p-tolyl sulfoxide

Base Information

• Chemical Name: (2S,R_S)-2-anilino-2-[4-(methoxyphenyl)]ethyl p-tolyl sulfoxide
• CAS No.: 121411-10-7
• Molecular Formula: C₂₂H₂₃NO₂S
• Molecular Weight: 365.496
• Mol file: 121411-10-7.mol

Synonyms:(2S,R_S)-2-anilino-2-[4-(methoxyphenyl)]ethyl p-tolyl sulfoxide

Chemical Property of (2S,R_S)-2-anilino-2-[4-(methoxyphenyl)]ethyl p-tolyl sulfoxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,R_S)-2-anilino-2-[4-(methoxyphenyl)]ethyl p-tolyl sulfoxide

There total 2 articles about (2S,R_S)-2-anilino-2-[4-(methoxyphenyl)]ethyl p-tolyl sulfoxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

(R)-methyl p-tolyl sulfoxide (1519-39-7) + N-(4-methoxybenzylidene)aniline (1613-96-3) → (2R,RS)-2-anilino-2-[4-(methoxyphenyl)]ethyl p-tolyl sulfoxide (121411-09-4) + (2S,RS)-2-anilino-2-[4-(methoxyphenyl)]ethyl p-tolyl sulfoxide (121411-10-7)

Guidance literature:

(R)-methyl p-tolyl sulfoxide; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

N-(4-methoxybenzylidene)aniline; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h;

DOI:10.1135/cccc20030885

Reference yield:

(R)-methyl p-tolyl sulfoxide (1519-39-7) + p-methoxybenzylidene-phenylamine (836-41-9) → (2R,RS)-2-anilino-2-[4-(methoxyphenyl)]ethyl p-tolyl sulfoxide (121411-09-4) + (2S,RS)-2-anilino-2-[4-(methoxyphenyl)]ethyl p-tolyl sulfoxide (121411-10-7)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction. Yields of byproduct given; 1) THF, 0 deg C; 2) THF, -78 deg C, 20 min;

DOI:10.1016/S0040-4039(00)82275-3

upstream raw materials:

(R)-methyl p-tolyl sulfoxide

p-methoxybenzylidene-phenylamine

N-(4-methoxybenzylidene)aniline