[5-[3-(1-methylpiperidin-3-yloxy)phenyl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide

Base Information

Chemical Name:[5-[3-(1-methylpiperidin-3-yloxy)phenyl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide
CAS No.:1449321-22-5
Molecular Formula:C₃₇H₃₆N₆O₄S
Molecular Weight:660.797
Hs Code.:

Synonyms:[5-[3-(1-methylpiperidin-3-yloxy)phenyl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide

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Chemical Property of [5-[3-(1-methylpiperidin-3-yloxy)phenyl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide

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Technology Process of [5-[3-(1-methylpiperidin-3-yloxy)phenyl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide

There total 7 articles about [5-[3-(1-methylpiperidin-3-yloxy)phenyl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1449319-84-9
1-benzyl-1H-pyrazol-4-carboxylic acid [5-bromo-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide

: 1449321-17-8
(S)-1-methyl-2-[3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenoxymethyl]pyrrolidine

: 1449321-20-3
1-benzyl-1H-pyrazol-4-carboxylic acid [5-[3-((S)-1-methylpyrrolidin-2-ylmethoxy)phenyl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide

: 1449321-22-5
[5-[3-(1-methylpiperidin-3-yloxy)phenyl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; potassium carbonate; In tetrahydrofuran; at 130 ℃; for 1h; Microwave irradiation;

Reference yield:

: 1449318-35-7
1-benzyl-1H-pyrazol-4-carboxylic acid (5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)amide

: 1449321-20-3
1-benzyl-1H-pyrazol-4-carboxylic acid [5-[3-((S)-1-methylpyrrolidin-2-ylmethoxy)phenyl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide

: 1449321-22-5
[5-[3-(1-methylpiperidin-3-yloxy)phenyl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / water; dichloromethane / 4 h / 20 °C

2: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water / tetrahydrofuran / 1 h / 130 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; sodium hydroxide; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 214360-76-6
3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

: 1449321-20-3
1-benzyl-1H-pyrazol-4-carboxylic acid [5-[3-((S)-1-methylpyrrolidin-2-ylmethoxy)phenyl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide

: 1449321-22-5
[5-[3-(1-methylpiperidin-3-yloxy)phenyl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide

Guidance literature:: Multi-step reaction with 2 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 36 h / 0 - 20 °C

2: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water / tetrahydrofuran / 1 h / 130 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; di-isopropyl azodicarboxylate; water; potassium carbonate; triphenylphosphine; In tetrahydrofuran;