2-benzyl-4-(4-fluorophenoxy)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone

Base Information

Chemical Name:2-benzyl-4-(4-fluorophenoxy)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone
CAS No.:213764-00-2
Molecular Formula:C₂₄H₁₉FN₂O₄S
Molecular Weight:450.49
Hs Code.:

Synonyms:2-benzyl-4-(4-fluorophenoxy)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone

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Chemical Property of 2-benzyl-4-(4-fluorophenoxy)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone

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Technology Process of 2-benzyl-4-(4-fluorophenoxy)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone

There total 9 articles about 2-benzyl-4-(4-fluorophenoxy)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 371-41-5
4-Fluorophenol

: 213764-20-6
2-benzyl-4-bromo-5-(4-methylsulfonyl)phenyl-2H-pyridazin-3-one

: 213764-00-2
2-benzyl-4-(4-fluorophenoxy)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone

Guidance literature:: With caesium carbonate; In DMF (N,N-dimethyl-formamide); at 70 - 80 ℃; for 3h;

Reference yield: 49.0%

: 371-41-5
4-Fluorophenol

Cs₂ CO₃: Cs₂ CO₃

: 7732-18-5
water

: 213763-99-6
2-Benzyl-4-(2-propoxy)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone

: 213764-00-2
2-benzyl-4-(4-fluorophenoxy)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone

Guidance literature:: In diethyl ether; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 98546-51-1
(4-thiomethoxyphenyl)boronic acid

: 213764-00-2
2-benzyl-4-(4-fluorophenoxy)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone

Guidance literature:: Multi-step reaction with 7 steps

1.1: 100 percent / Na₂CO₃; PdCl₂(PPh₃)2 / benzene; ethanol

2.1: Br₂ / CH₂Cl₂

2.2: MMPP

3.1: NBS

4.1: aq. AcOH / tetrahydrofuran

5.1: 84 percent / NH₂NH₂

6.1: base

7.1: K₂CO₃ / dimethylformamide

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; bromine; sodium carbonate; potassium carbonate; acetic acid; hydrazine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; benzene; 1.1: Suzuki coupling;
DOI:10.1016/S0960-894X(02)01045-4