(+)-tert-butyl-((1S,2S,3S)-3-(4-methoxybenzyloxy)-2-methyl-2-((S)-2-(7-methyl-1,4-dioxa-spiro[4.4]non-7-yl)-ethyl)-cyclohexyl)-dimethyl-silane

Base Information

Chemical Name:(+)-tert-butyl-((1S,2S,3S)-3-(4-methoxybenzyloxy)-2-methyl-2-((S)-2-(7-methyl-1,4-dioxa-spiro[4.4]non-7-yl)-ethyl)-cyclohexyl)-dimethyl-silane
CAS No.:824940-69-4
Molecular Formula:C₃₁H₅₂O₅Si
Molecular Weight:532.836
Hs Code.:

Synonyms:(+)-tert-butyl-((1S,2S,3S)-3-(4-methoxybenzyloxy)-2-methyl-2-((S)-2-(7-methyl-1,4-dioxa-spiro[4.4]non-7-yl)-ethyl)-cyclohexyl)-dimethyl-silane

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Chemical Property of (+)-tert-butyl-((1S,2S,3S)-3-(4-methoxybenzyloxy)-2-methyl-2-((S)-2-(7-methyl-1,4-dioxa-spiro[4.4]non-7-yl)-ethyl)-cyclohexyl)-dimethyl-silane

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Technology Process of (+)-tert-butyl-((1S,2S,3S)-3-(4-methoxybenzyloxy)-2-methyl-2-((S)-2-(7-methyl-1,4-dioxa-spiro[4.4]non-7-yl)-ethyl)-cyclohexyl)-dimethyl-silane

There total 13 articles about (+)-tert-butyl-((1S,2S,3S)-3-(4-methoxybenzyloxy)-2-methyl-2-((S)-2-(7-methyl-1,4-dioxa-spiro[4.4]non-7-yl)-ethyl)-cyclohexyl)-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 824940-68-3
dithiocarbonic acid O-[2-[(1S,2S,6S)-2-(tert-butyl-dimethylsilanyloxy)-6-(4-methoxybenzyloxy)-1-methylcyclohexyloxy]-1-[(7S)-7-methyl-1,4-dioxa-spiro[4.4]non-7-yl]-ethyl] ester S-methyl ester

: 824940-69-4
(+)-tert-butyl-((1S,2S,3S)-3-(4-methoxybenzyloxy)-2-methyl-2-((S)-2-(7-methyl-1,4-dioxa-spiro[4.4]non-7-yl)-ethyl)-cyclohexyl)-dimethyl-silane

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; for 2h; Heating;
DOI:10.1021/ol048010i

Reference yield:

: 619335-63-6
(1S,3S)-2-benzyloxymethyl-2-methylcyclohexane-1,3-diol

: 824940-69-4
(+)-tert-butyl-((1S,2S,3S)-3-(4-methoxybenzyloxy)-2-methyl-2-((S)-2-(7-methyl-1,4-dioxa-spiro[4.4]non-7-yl)-ethyl)-cyclohexyl)-dimethyl-silane

Guidance literature:: Multi-step reaction with 8 steps

1.1: 100 percent / H₂ / Raney Ni / 12 h / 20 °C

2.1: 90 percent / CSA / CH₂Cl₂ / 2 h / 20 °C

3.1: 100 percent / DIPEA / 1 h / 20 °C

4.1: 97 percent / DIBAL-H / hexane / 4 h / 20 °C

5.1: 93 percent / PPh₃; I₂ / benzene / Heating

6.1: t-BuLi / diethyl ether; tetrahydrofuran / -78 °C

6.2: 79 percent / diethyl ether; tetrahydrofuran / -78 - 20 °C

7.1: 91 percent / NHMDS / 10 h / 20 °C

8.1: 89 percent / n-Bu₃SnH; AIBN / toluene / 2 h / Heating

With 2,2'-azobis(isobutyronitrile); camphor-10-sulfonic acid; hydrogen; iodine; tert.-butyl lithium; tri-n-butyl-tin hydride; sodium hexamethyldisilazane; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; nickel; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; toluene; benzene;
DOI:10.1021/ol048010i

Reference yield:

: 824940-78-5
(S)-7-methyl-7-phenylsulfanylmethyl-1,4-dioxa-spiro[4.4]nonane

: 824940-69-4
(+)-tert-butyl-((1S,2S,3S)-3-(4-methoxybenzyloxy)-2-methyl-2-((S)-2-(7-methyl-1,4-dioxa-spiro[4.4]non-7-yl)-ethyl)-cyclohexyl)-dimethyl-silane

Guidance literature:: Multi-step reaction with 5 steps

1.1: 100 percent / m-CPBA / CH₂Cl₂ / 1 h / -40 °C

2.1: 87 percent / TFAA; TEA / 3 h / 20 °C

3.1: t-BuLi / diethyl ether; tetrahydrofuran / -78 °C

3.2: 79 percent / diethyl ether; tetrahydrofuran / -78 - 20 °C

4.1: 91 percent / NHMDS / 10 h / 20 °C

5.1: 89 percent / n-Bu₃SnH; AIBN / toluene / 2 h / Heating

With 2,2'-azobis(isobutyronitrile); TEA; tert.-butyl lithium; tri-n-butyl-tin hydride; sodium hexamethyldisilazane; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;
DOI:10.1021/ol048010i