Technology Process of 2-(diisopropylcarbamoyl)benzene-1,4-diol
There total 14 articles about 2-(diisopropylcarbamoyl)benzene-1,4-diol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
boron tribromide-dimethyl sulfide complex;
In
dichloromethane;
for 6h;
Heating;
DOI:10.1039/b004682p
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 85 percent / pyridine
2.1: sec-butyllithium; TMEDA / tetrahydrofuran; hexane / -78 °C
2.2: 91 percent / tetrahydrofuran; hexane / 15 h / -78 - 20 °C
3.1: 60 percent / boron tribromide dimethylsulfide complex / CH2Cl2 / 6 h / Heating
With
pyridine; boron tribromide-dimethyl sulfide complex; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium;
In
tetrahydrofuran; hexane; dichloromethane;
1.1: Acylation / 2.1: Metallation / 2.2: Rearrangement / 3.1: Demethylation;
DOI:10.1039/b004682p
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 92 percent / pyridine
2.1: sec-butyllithium; TMEDA / tetrahydrofuran; hexane / -78 °C
2.2: 71 percent / tetrahydrofuran; hexane / 15 h / -78 - 20 °C
3.1: n-butyllithium / tetrahydrofuran; hexane / 0 °C
3.2: 93 percent / tetrahydrofuran; hexane / 0 - 20 °C
4.1: LDA / tetrahydrofuran; hexane / 1 h / -78 °C
4.2: 32 percent Spectr. / aq. NH4Cl / tetrahydrofuran; hexane / -78 - 20 °C
5.1: 60 percent / boron tribromide dimethylsulfide complex / CH2Cl2 / 6 h / Heating
With
pyridine; n-butyllithium; boron tribromide-dimethyl sulfide complex; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; lithium diisopropyl amide;
In
tetrahydrofuran; hexane; dichloromethane;
1.1: Acylation / 2.1: Metallation / 2.2: Rearrangement / 3.1: Metallation / 3.2: Esterification / 4.1: Metallation / 4.2: Hydrolysis / 5.1: Demethylation;
DOI:10.1039/b004682p
