ethyl 4-(3-azidophenyl)-6-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Base Information

Chemical Name:ethyl 4-(3-azidophenyl)-6-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS No.:1400981-66-9
Molecular Formula:C₁₄H₁₅N₅O₂S
Molecular Weight:317.371
Hs Code.:

Synonyms:ethyl 4-(3-azidophenyl)-6-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate

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Chemical Property of ethyl 4-(3-azidophenyl)-6-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate

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Technology Process of ethyl 4-(3-azidophenyl)-6-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate

There total 5 articles about ethyl 4-(3-azidophenyl)-6-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 898291-38-8
ethyl 4-(3-aminophenyl)-6-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 1400981-66-9
ethyl 4-(3-azidophenyl)-6-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: ethyl 4-(3-aminophenyl)-6-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate; With hydrogenchloride; sodium nitrite; In water; acetone; at -5 - 0 ℃; for 0.5h; Inert atmosphere;

With sodium azide; In ethanol; water; at -5 ℃; for 1h; Solvent; Inert atmosphere; Darkness;
DOI:10.3987/COM-17-13766

Reference yield: 92.0%

: 42460-46-8
3-azidobenzoaldehyde

: 141-97-9
ethyl acetoacetate

: 17356-08-0
thiourea

: 1400981-66-9
ethyl 4-(3-azidophenyl)-6-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: With iodine; at 60 ℃; for 0.333333h; Microwave irradiation;
DOI:10.1080/00397911.2011.593289

Reference yield:

: 141-97-9
ethyl acetoacetate

: 1400981-66-9
ethyl 4-(3-azidophenyl)-6-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: aluminum (III) chloride / ethanol / 6 h / Reflux; Inert atmosphere

2.1: zinc; acetic acid / ethanol / 6 h / 20 °C / Inert atmosphere

3.1: sodium nitrite; hydrogenchloride / water; acetone / 0.5 h / -5 - 0 °C / Inert atmosphere

3.2: 1 h / -5 °C / Inert atmosphere; Darkness

With hydrogenchloride; aluminum (III) chloride; acetic acid; zinc; sodium nitrite; In ethanol; water; acetone; 1.1: |Biginelli Pyrimidone Synthesis;
DOI:10.3987/COM-17-13766