3-[acetyl-[2-[[(tert-butylamino)carbonyl]amino]-3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-7-yl]amino]propyl acetate

Base Information

Chemical Name:3-[acetyl-[2-[[(tert-butylamino)carbonyl]amino]-3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-7-yl]amino]propyl acetate
CAS No.:862370-18-1
Molecular Formula:C₂₈H₃₅N₅O₆
Molecular Weight:537.616
Hs Code.:

Synonyms:3-[acetyl-[2-[[(tert-butylamino)carbonyl]amino]-3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-7-yl]amino]propyl acetate

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Chemical Property of 3-[acetyl-[2-[[(tert-butylamino)carbonyl]amino]-3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-7-yl]amino]propyl acetate

Chemical Property:

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Technology Process of 3-[acetyl-[2-[[(tert-butylamino)carbonyl]amino]-3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-7-yl]amino]propyl acetate

There total 1 articles about 3-[acetyl-[2-[[(tert-butylamino)carbonyl]amino]-3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-7-yl]amino]propyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 862370-15-8
N-[2-(3-tert-butyl-ureido)-3-(3,5-dimethoxy-phenyl)-[1,6]naphthyridin-7-yl]-N-(3-hydroxy-propyl)-acetamide

: 108-24-7
acetic anhydride

: N-[3-(benzyloxy)propyl]-N-[3-(3,5-dimethoxyphenyl)-1,2,3,4-tetrahydro-1,6-naphthyridin-7-yl]acetamide

: 862370-18-1
3-[acetyl-[2-[[(tert-butylamino)carbonyl]amino]-3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-7-yl]amino]propyl acetate

Guidance literature:: With pyridine; at 20 ℃; for 14h;
DOI:10.1021/jm0500931

Reference yield: 94.0%

: 862370-18-1
3-[acetyl-[2-[[(tert-butylamino)carbonyl]amino]-3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-7-yl]amino]propyl acetate

: 862370-15-8
N-[2-(3-tert-butyl-ureido)-3-(3,5-dimethoxy-phenyl)-[1,6]naphthyridin-7-yl]-N-(3-hydroxy-propyl)-acetamide

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃; for 1h;
DOI:10.1021/jm0500931

Reference yield:

: 862370-18-1
3-[acetyl-[2-[[(tert-butylamino)carbonyl]amino]-3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-7-yl]amino]propyl acetate

: 1-tert-butyl-3-[7-(3-diethylamino-propylamino)-3-(3,5-dimethoxy-phenyl)-[1,6]naphthyridin-2-yl]-urea

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / K₂CO₃ / methanol / 1 h / 20 °C

2: N-methylmorpholine / tetrahydrofuran / 12 h / 0 - 20 °C

3: 26 mg / tetrahydrofuran / 42 h / 50 °C

4: 83 percent / aq. NaOH / methanol / 0 - 20 °C

With 4-methyl-morpholine; sodium hydroxide; potassium carbonate; In tetrahydrofuran; methanol;
DOI:10.1021/jm0500931