3-acetoxy-9-acetyl-2-(4-chloro-benzyl)-7,8,9,10-tetrahydro-[1,9]phenanthroline-4-carboxylic acid

Base Information

Chemical Name:3-acetoxy-9-acetyl-2-(4-chloro-benzyl)-7,8,9,10-tetrahydro-[1,9]phenanthroline-4-carboxylic acid
CAS No.:851548-07-7
Molecular Formula:C₂₄H₂₁ClN₂O₅
Molecular Weight:452.894
Hs Code.:

Synonyms:3-acetoxy-9-acetyl-2-(4-chloro-benzyl)-7,8,9,10-tetrahydro-[1,9]phenanthroline-4-carboxylic acid

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Chemical Property of 3-acetoxy-9-acetyl-2-(4-chloro-benzyl)-7,8,9,10-tetrahydro-[1,9]phenanthroline-4-carboxylic acid

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Technology Process of 3-acetoxy-9-acetyl-2-(4-chloro-benzyl)-7,8,9,10-tetrahydro-[1,9]phenanthroline-4-carboxylic acid

There total 11 articles about 3-acetoxy-9-acetyl-2-(4-chloro-benzyl)-7,8,9,10-tetrahydro-[1,9]phenanthroline-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(4-chloro-benzyl)-3-hydroxy-7,8,9,10-tetrahydro-[1,9]phenanthroline-4-carboxylic acid hydrochloride

: 108-24-7
acetic anhydride

: 851548-07-7
3-acetoxy-9-acetyl-2-(4-chloro-benzyl)-7,8,9,10-tetrahydro-[1,9]phenanthroline-4-carboxylic acid

Guidance literature:: With triethylamine; In pyridine; at 0 - 25 ℃;

Reference yield:

: 851548-02-2
8-acetyl-6,7,8,9-tetrahydro-1H-pyrrolo[3,2-h]isoquinoline-2,3-dione

: 851548-07-7
3-acetoxy-9-acetyl-2-(4-chloro-benzyl)-7,8,9,10-tetrahydro-[1,9]phenanthroline-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 16 percent / aq. NaOH / ethanol / 2 h / Heating

2: pyridine; Et₃N / 25 °C

With pyridine; sodium hydroxide; triethylamine; In ethanol; 1: Pfitzinger reaction;
DOI:10.1021/jm060631p

Reference yield:

: 25026-34-0
4-chlorophenacetyl chloride

: 851548-07-7
3-acetoxy-9-acetyl-2-(4-chloro-benzyl)-7,8,9,10-tetrahydro-[1,9]phenanthroline-4-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: diethyl ether; tetrahydrofuran

1.2: 74 percent / HCl / diethyl ether; tetrahydrofuran

2.1: 55 percent / AcOH / ethanol / 3 h / Heating

3.1: 16 percent / aq. NaOH / ethanol / 2 h / Heating

4.1: pyridine; Et₃N / 25 °C

With pyridine; sodium hydroxide; acetic acid; triethylamine; In tetrahydrofuran; diethyl ether; ethanol; 3.1: Pfitzinger reaction;
DOI:10.1021/jm060631p