(Z)-(2R,4S,5R)-(-)-(3-bromo-2-methyl-allyl)-(4-isopropyl-2-phenyl-[1,3]dioxan-5-yl)-amine

Base Information

Chemical Name:(Z)-(2R,4S,5R)-(-)-(3-bromo-2-methyl-allyl)-(4-isopropyl-2-phenyl-[1,3]dioxan-5-yl)-amine
CAS No.:870527-71-2
Molecular Formula:C₁₇H₂₄BrNO₂
Molecular Weight:354.287
Hs Code.:

Synonyms:(Z)-(2R,4S,5R)-(-)-(3-bromo-2-methyl-allyl)-(4-isopropyl-2-phenyl-[1,3]dioxan-5-yl)-amine

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Chemical Property of (Z)-(2R,4S,5R)-(-)-(3-bromo-2-methyl-allyl)-(4-isopropyl-2-phenyl-[1,3]dioxan-5-yl)-amine

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Technology Process of (Z)-(2R,4S,5R)-(-)-(3-bromo-2-methyl-allyl)-(4-isopropyl-2-phenyl-[1,3]dioxan-5-yl)-amine

There total 5 articles about (Z)-(2R,4S,5R)-(-)-(3-bromo-2-methyl-allyl)-(4-isopropyl-2-phenyl-[1,3]dioxan-5-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 870527-70-1
(2R,4S,5R)-(-)-5-azido-4-isopropyl-2-phenyl[1,3]dioxane

: 870527-71-2
(Z)-(2R,4S,5R)-(-)-(3-bromo-2-methyl-allyl)-(4-isopropyl-2-phenyl-[1,3]dioxan-5-yl)-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 98 percent / H₂ / Pd/CaCO₃ / ethanol / 3 h / 20 °C / 760 Torr

2.1: K₂CO₃ / acetonitrile / 0.5 h / 40 °C

2.2: acetonitrile / 18 h / Heating

With hydrogen; potassium carbonate; Lindlar's catalyst; In ethanol; acetonitrile;
DOI:10.1039/b508300a

Reference yield:

: 870527-57-4
(2R,3S)-(-)-2-azido-4-methyl-1-pentane-1,3-diol

: 870527-71-2
(Z)-(2R,4S,5R)-(-)-(3-bromo-2-methyl-allyl)-(4-isopropyl-2-phenyl-[1,3]dioxan-5-yl)-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 78 percent / p-toluenesulfonic acid monohydrate / toluene / 1 h / Heating

2.1: 98 percent / H₂ / Pd/CaCO₃ / ethanol / 3 h / 20 °C / 760 Torr

3.1: K₂CO₃ / acetonitrile / 0.5 h / 40 °C

3.2: acetonitrile / 18 h / Heating

With hydrogen; potassium carbonate; toluene-4-sulfonic acid; Lindlar's catalyst; In ethanol; toluene; acetonitrile;
DOI:10.1039/b508300a

Reference yield:

: 69143-05-1
(E)-4-methyl-pent-2-en-1-ol

: 870527-71-2
(Z)-(2R,4S,5R)-(-)-(3-bromo-2-methyl-allyl)-(4-isopropyl-2-phenyl-[1,3]dioxan-5-yl)-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 76 percent / (+)-diisopropyl L-tartrate; tert-butyl hydroperoxide; Ti(O-i-Pr)4 / 4 Angstroem molecular sieves / CH₂Cl₂; decane / 7 h / -20 °C

2.1: NH₄Cl; aq. NaN₃ / 2-methoxy-ethanol / 14 h / Heating

2.2: 47 percent / aq. NaIO₄ / tetrahydrofuran; 2-methoxy-ethanol / 24 h / 20 °C

3.1: 78 percent / p-toluenesulfonic acid monohydrate / toluene / 1 h / Heating

4.1: 98 percent / H₂ / Pd/CaCO₃ / ethanol / 3 h / 20 °C / 760 Torr

5.1: K₂CO₃ / acetonitrile / 0.5 h / 40 °C

5.2: acetonitrile / 18 h / Heating

With titanium(IV) isopropylate; tert.-butylhydroperoxide; sodium azide; L-(+)-diisopropyl tartrate; hydrogen; potassium carbonate; ammonium chloride; toluene-4-sulfonic acid; Lindlar's catalyst; 4 A molecular sieve; In decane; ethanol; dichloromethane; 2-methoxy-ethanol; toluene; acetonitrile; 1.1: Sharpless asymmetric epoxidation;
DOI:10.1039/b508300a