3-(4-(4-(2-(1H-imidazol-1-yl)ethyl)piperazin-1-yl)butoxy)-2-aminophenol

Base Information

Chemical Name:3-(4-(4-(2-(1H-imidazol-1-yl)ethyl)piperazin-1-yl)butoxy)-2-aminophenol
CAS No.:1372616-32-4
Molecular Formula:C₁₉H₂₉N₅O₂
Molecular Weight:359.472
Hs Code.:

Synonyms:3-(4-(4-(2-(1H-imidazol-1-yl)ethyl)piperazin-1-yl)butoxy)-2-aminophenol

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Chemical Property of 3-(4-(4-(2-(1H-imidazol-1-yl)ethyl)piperazin-1-yl)butoxy)-2-aminophenol

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Technology Process of 3-(4-(4-(2-(1H-imidazol-1-yl)ethyl)piperazin-1-yl)butoxy)-2-aminophenol

There total 5 articles about 3-(4-(4-(2-(1H-imidazol-1-yl)ethyl)piperazin-1-yl)butoxy)-2-aminophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1372616-30-2
1-(2-(1H-imidazol-1-yl ) ethyl)-4-(4-(3-(benzyloxy)-2-nitrophenoxy)butyl)piperazine

: 1372616-32-4
3-(4-(4-(2-(1H-imidazol-1-yl)ethyl)piperazin-1-yl)butoxy)-2-aminophenol

Guidance literature:: With hydrogenchloride; 20 % Pd(OH)2/C; hydrogen; In methanol; water; for 40h; under 2068.65 Torr;
DOI:10.1021/jm201716n

Reference yield:

: 1372616-29-9
1-(benzyloxy)-3-(4-bromobutoxy)-2-nitrobenzene

: 1372616-32-4
3-(4-(4-(2-(1H-imidazol-1-yl)ethyl)piperazin-1-yl)butoxy)-2-aminophenol

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / Reflux

2: hydrogenchloride; 20 % Pd(OH)2/C; hydrogen / methanol; water / 40 h / 2068.65 Torr

With hydrogenchloride; 20 % Pd(OH)2/C; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; water; acetonitrile;
DOI:10.1021/jm201716n

Reference yield:

: 213685-59-7
2-nitroresorcinol monobenzyl ether

: 1372616-32-4
3-(4-(4-(2-(1H-imidazol-1-yl)ethyl)piperazin-1-yl)butoxy)-2-aminophenol

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 25 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / Reflux

3: hydrogenchloride; 20 % Pd(OH)2/C; hydrogen / methanol; water / 40 h / 2068.65 Torr

With hydrogenchloride; 20 % Pd(OH)2/C; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm201716n