2-(3'-hydroxy-6'-ethoxy-9'H-xanthen-9'-yl)phenylethyl alcohol

Base Information

• Chemical Name: 2-(3'-hydroxy-6'-ethoxy-9'H-xanthen-9'-yl)phenylethyl alcohol
• CAS No.: 1374021-47-2
• Molecular Formula: C₂₂H₂₀O₄
• Molecular Weight: 348.398
• Mol file: 1374021-47-2.mol

Synonyms:2-(3'-hydroxy-6'-ethoxy-9'H-xanthen-9'-yl)phenylethyl alcohol

Chemical Property of 2-(3'-hydroxy-6'-ethoxy-9'H-xanthen-9'-yl)phenylethyl alcohol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3'-hydroxy-6'-ethoxy-9'H-xanthen-9'-yl)phenylethyl alcohol

There total 2 articles about 2-(3'-hydroxy-6'-ethoxy-9'H-xanthen-9'-yl)phenylethyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2-(6'-ethoxy-3'-oxo-3'H-xanthene-9'-yl)benzoic acid ethyl ester (87569-96-8) → 2-(3'-hydroxy-6'-ethoxy-9'H-xanthen-9'-yl)phenylethyl alcohol (1374021-47-2)

Guidance literature:

2-(6'-ethoxy-3'-oxo-3'H-xanthene-9'-yl)benzoic acid ethyl ester; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 2.5h;

With hydrogenchloride; In tetrahydrofuran; water;

DOI:10.1039/c2cc30265a

Reference yield:

fluorescein free acid (518-45-6) → 2-(3'-hydroxy-6'-ethoxy-9'H-xanthen-9'-yl)phenylethyl alcohol (1374021-47-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 24 h / 60 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / 0 °C

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; acetonitrile;

DOI:10.1039/c2cc30265a

upstream raw materials:

2-(6'-ethoxy-3'-oxo-3'H-xanthene-9'-yl)benzoic acid ethyl ester

fluorescein free acid