5'-O-(tert-Butyldimethylsilyl)-3'-O-(tert-butyldiphenylsilyl)-4-(1,2,4-triazolyl)thymidine

Base Information

• Chemical Name: 5'-O-(tert-Butyldimethylsilyl)-3'-O-(tert-butyldiphenylsilyl)-4-(1,2,4-triazolyl)thymidine
• CAS No.: 158813-59-3
• Molecular Formula: C₃₄H₄₇N₅O₄Si₂
• Molecular Weight: 645.949

Synonyms:5'-O-(tert-Butyldimethylsilyl)-3'-O-(tert-butyldiphenylsilyl)-4-(1,2,4-triazolyl)thymidine

Chemical Property of 5'-O-(tert-Butyldimethylsilyl)-3'-O-(tert-butyldiphenylsilyl)-4-(1,2,4-triazolyl)thymidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-(tert-Butyldimethylsilyl)-3'-O-(tert-butyldiphenylsilyl)-4-(1,2,4-triazolyl)thymidine

There total 3 articles about 5'-O-(tert-Butyldimethylsilyl)-3'-O-(tert-butyldiphenylsilyl)-4-(1,2,4-triazolyl)thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → 5'-O-(tert-Butyldimethylsilyl)-3'-O-(tert-butyldiphenylsilyl)-4-(1,2,4-triazolyl)thymidine (158813-59-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / imidazole / dimethylformamide / 16 h / Ambient temperature

2: 1.) POCl₃, Et₃N / 1.) MeCN, 0 deg C, 1 h, 2.) r.t., 3 h

With 1H-imidazole; triethylamine; trichlorophosphate; In N,N-dimethyl-formamide;

DOI:10.1021/jo00121a037

Reference yield:

5'-tert-butyldimethylsilyloxy-2'-deoxythymidine (40733-28-6) → 5'-O-(tert-Butyldimethylsilyl)-3'-O-(tert-butyldiphenylsilyl)-4-(1,2,4-triazolyl)thymidine (158813-59-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / imidazole / dimethylformamide / 16 h / Ambient temperature

2: 1.) POCl₃, Et₃N / 1.) MeCN, 0 deg C, 1 h, 2.) r.t., 3 h

With 1H-imidazole; triethylamine; trichlorophosphate; In N,N-dimethyl-formamide;

DOI:10.1021/jo00121a037

Reference yield:

1,2,4-Triazole (288-88-0) + 5'-O-(tert-butyldimethylsilyl)-3'-O-(tert-butyldiphenylsilyl)thymidine (166758-13-0) → 5'-O-(tert-Butyldimethylsilyl)-3'-O-(tert-butyldiphenylsilyl)-4-(1,2,4-triazolyl)thymidine (158813-59-3)

Guidance literature:

With triethylamine; trichlorophosphate; Yield given. Multistep reaction; 1.) MeCN, 0 deg C, 1 h, 2.) r.t., 3 h;

DOI:10.1021/jo00121a037

upstream raw materials:

1,2,4-Triazole

5'-O-(tert-butyldimethylsilyl)-3'-O-(tert-butyldiphenylsilyl)thymidine

tert-butylchlorodiphenylsilane

5'-tert-butyldimethylsilyloxy-2'-deoxythymidine

Downstream raw materials:

N⁴-Benzoyl-5'-O-(tert-butyldimethylsilyl)-3'-O-(tert-butyldiphenylsilyl)-5-methyl-2'-deoxycytidine

N⁴-Benzoyl-3'-O-(tert-butyldiphenylsilyl)-5-methyl-2'-deoxycytidine

5'-O-Phthalimido-N⁴-benzoyl-3'-O-(tert-butyldiphenylsilyl)-5-methyl-2'-deoxycytidine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 158813-59-3 5'-O-(tert-Butyldimethylsilyl)-3'-O-(tert-butyldiphenylsilyl)-4-(1,2,4-triazolyl)thymidine

Send

Send

Metric Ton KG G Pound L ML

Send

Send