2-{[4-(6-acetamidopyridin-3-yl)phenyl]amino}-N-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl]acetamide

Base Information

Chemical Name:2-{[4-(6-acetamidopyridin-3-yl)phenyl]amino}-N-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl]acetamide
CAS No.:1613168-67-4
Molecular Formula:C₂₇H₂₉F₃N₆O₂
Molecular Weight:526.561
Hs Code.:

Synonyms:2-{[4-(6-acetamidopyridin-3-yl)phenyl]amino}-N-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl]acetamide

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Chemical Property of 2-{[4-(6-acetamidopyridin-3-yl)phenyl]amino}-N-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl]acetamide

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Technology Process of 2-{[4-(6-acetamidopyridin-3-yl)phenyl]amino}-N-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl]acetamide

There total 6 articles about 2-{[4-(6-acetamidopyridin-3-yl)phenyl]amino}-N-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₇H₄₅F₃N₆O₆

: 1613168-67-4
2-{[4-(6-acetamidopyridin-3-yl)phenyl]amino}-N-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl]acetamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: C₃₂H₃₇F₃N₆O₄

: 1613168-67-4
2-{[4-(6-acetamidopyridin-3-yl)phenyl]amino}-N-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl]acetamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane;
DOI:10.1021/acs.jmedchem.5b01712

Reference yield:

: 859027-30-8
4-(4-amino-2-trifluoromethyl-benzyl)-piperazine-1-carboxylic acid tert-butyl ester

: 1613168-67-4
2-{[4-(6-acetamidopyridin-3-yl)phenyl]amino}-N-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / tetrahydrofuran / 14 h / 20 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / water; 1,4-dioxane / 100 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; triethylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 2: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.5b01712