(1R,3R,3aS,4S,5R,6R,7R,7aR)-7-tert-butyldimethylsiloxy-1-[(1S)-hydroxy[4-methoxy-3-(methoxymethoxy)phenyl]methyl]-3-hydroxymethyl-5,6-(isopropylidenedioxy)octahydroindene-4-ol

Base Information

Chemical Name:(1R,3R,3aS,4S,5R,6R,7R,7aR)-7-tert-butyldimethylsiloxy-1-[(1S)-hydroxy[4-methoxy-3-(methoxymethoxy)phenyl]methyl]-3-hydroxymethyl-5,6-(isopropylidenedioxy)octahydroindene-4-ol
CAS No.:623550-26-5
Molecular Formula:C₂₉H₄₈O₉Si
Molecular Weight:568.78
Hs Code.:

(1R,3R,3aS,4S,5R,6R,7R,7aR)-7-tert-butyldimethylsiloxy-1-[(1S)-hydroxy[4-methoxy-3-(methoxymethoxy)phenyl]methyl]-3-hydroxymethyl-5,6-(isopropylidenedioxy)octahydroindene-4-ol

Synonyms:(1R,3R,3aS,4S,5R,6R,7R,7aR)-7-tert-butyldimethylsiloxy-1-[(1S)-hydroxy[4-methoxy-3-(methoxymethoxy)phenyl]methyl]-3-hydroxymethyl-5,6-(isopropylidenedioxy)octahydroindene-4-ol

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Chemical Property of (1R,3R,3aS,4S,5R,6R,7R,7aR)-7-tert-butyldimethylsiloxy-1-[(1S)-hydroxy[4-methoxy-3-(methoxymethoxy)phenyl]methyl]-3-hydroxymethyl-5,6-(isopropylidenedioxy)octahydroindene-4-ol

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Technology Process of (1R,3R,3aS,4S,5R,6R,7R,7aR)-7-tert-butyldimethylsiloxy-1-[(1S)-hydroxy[4-methoxy-3-(methoxymethoxy)phenyl]methyl]-3-hydroxymethyl-5,6-(isopropylidenedioxy)octahydroindene-4-ol

There total 9 articles about (1R,3R,3aS,4S,5R,6R,7R,7aR)-7-tert-butyldimethylsiloxy-1-[(1S)-hydroxy[4-methoxy-3-(methoxymethoxy)phenyl]methyl]-3-hydroxymethyl-5,6-(isopropylidenedioxy)octahydroindene-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 623550-22-1
(1R,3R,3aR,4R,5R,6R,7S,7aR)-4-tert-butyldimethylsiloxy-7-hydroxy-3-[(1S)-hydroxy[4-methoxy-3-(methoxymethoxy)phenyl]methyl]-5,6-(isopropylidenedioxy)octahydroindene-1-carbaldehyde

: 623550-26-5
(1R,3R,3aS,4S,5R,6R,7R,7aR)-7-tert-butyldimethylsiloxy-1-[(1S)-hydroxy[4-methoxy-3-(methoxymethoxy)phenyl]methyl]-3-hydroxymethyl-5,6-(isopropylidenedioxy)octahydroindene-4-ol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.0166667h;
DOI:10.1021/ol035443x DOI:10.1002/chem.200700789

Reference yield:

: 37942-01-1
5-bromo-2-methoxyphenol

: 623550-26-5
(1R,3R,3aS,4S,5R,6R,7R,7aR)-7-tert-butyldimethylsiloxy-1-[(1S)-hydroxy[4-methoxy-3-(methoxymethoxy)phenyl]methyl]-3-hydroxymethyl-5,6-(isopropylidenedioxy)octahydroindene-4-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 88 percent / iPr₂NEt / CH₂Cl₂ / 4 h / 0 - 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: 80 percent / tetrahydrofuran; hexane / 1 h / -78 °C

3.1: 30 percent / DBU / toluene / 1.5 h / Heating

4.1: 96 percent / LiAlH₄ / tetrahydrofuran / 0.02 h / 0 °C

With lithium aluminium tetrahydride; n-butyllithium; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; dichloromethane; toluene;
DOI:10.1021/ol035443x

Reference yield:

: 531-37-3
2-methoxyphenyl benzoate

: 623550-26-5
(1R,3R,3aS,4S,5R,6R,7R,7aR)-7-tert-butyldimethylsiloxy-1-[(1S)-hydroxy[4-methoxy-3-(methoxymethoxy)phenyl]methyl]-3-hydroxymethyl-5,6-(isopropylidenedioxy)octahydroindene-4-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: Br₂; AcOH / 20 °C

2.1: K₂CO₃ / methanol / 20 °C

3.1: 88 percent / iPr₂NEt / CH₂Cl₂ / 4 h / 0 - 20 °C

4.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

4.2: 80 percent / tetrahydrofuran; hexane / 1 h / -78 °C

5.1: 30 percent / DBU / toluene / 1.5 h / Heating

6.1: 96 percent / LiAlH₄ / tetrahydrofuran / 0.02 h / 0 °C

With lithium aluminium tetrahydride; n-butyllithium; bromine; potassium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; hexane; dichloromethane; toluene;
DOI:10.1021/ol035443x