ND₀₁₁₇

Base Information

Chemical Name:ND₀₁₁₇
CAS No.:1240322-37-5
Molecular Formula:C₃₀H₃₂N₆O₄
Molecular Weight:540.622
Hs Code.:

Synonyms:ND₀₁₁₇

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ND₀₁₁₇

Chemical Property:

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Technology Process of ND₀₁₁₇

There total 5 articles about ND₀₁₁₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1616629-04-9
5-(5-amino-2-methylbenzoylamino)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester

: 106261-48-7
4-(4-methylpiperazin-1-ylmethyl)benzoic acid

: 1240322-37-5
ND₀₁₁₇

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; Schlenk technique; Inert atmosphere;
DOI:10.1021/acs.jmedchem.6b00087

Reference yield: 8.0%

: 952182-18-2
5-amino-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester

: 1240322-40-0
5-(4-((4-methylpiperazin-1-yl)methyl)benzamido)-2-methylbenzoic acid

: 1240322-37-5
ND₀₁₁₇

Guidance literature:: 5-amino-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester; 5-(4-((4-methylpiperazin-1-yl)methyl)benzamido)-2-methylbenzoic acid; With benzotriazol-1-ol; triethylamine; In dichloromethane; at 20 ℃; for 0.25h;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 16h;

Reference yield:

: 1975-52-6
5-nitro-o-toluic acid

: 1240322-37-5
ND₀₁₁₇

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 26252.6 Torr

3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Schlenk technique; Inert atmosphere

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.6b00087