Picolinic acid, 4-methyl-, hydrazide (8CI)

Base Information

• Chemical Name: Picolinic acid, 4-methyl-, hydrazide (8CI)
• CAS No.: 34285-72-8
• Molecular Formula: C7H9 N3 O
• Molecular Weight: 151.16586
• Hs Code.: 2933399090
• Mol file: 34285-72-8.mol

Synonyms:Picolinicacid, 4-methyl-, hydrazide (8CI); 4-Methylpicolinic acid hydrazide

Chemical Property of Picolinic acid, 4-methyl-, hydrazide (8CI)

Chemical Property:

• PSA: 68.01000
• LogP: 1.08470

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Picolinic acid, 4-methyl-, hydrazide (8CI)

There total 4 articles about Picolinic acid, 4-methyl-, hydrazide (8CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4-methyl-2-pyridinecarboxylate (58997-09-4) → 4-methylpicolinohydrazide (34285-72-8)

Guidance literature:

With ethanol; hydrazine hydrate;

Reference yield:

4-methylpicolinic acid (4021-08-3) → 4-methylpicolinohydrazide (34285-72-8)

Guidance literature:

Multi-step reaction with 2 steps

1: concentrated H₂SO₄

2: aqueous ethanol; N₂H₄+H₂O

With ethanol; sulfuric acid; hydrazine hydrate;

Reference yield:

2,4-lutidine (108-47-4) → 4-methylpicolinohydrazide (34285-72-8)

Guidance literature:

Multi-step reaction with 3 steps

1: aqueous KMnO₄

2: concentrated H₂SO₄

3: aqueous ethanol; N₂H₄+H₂O

With potassium permanganate; ethanol; sulfuric acid; hydrazine hydrate;

upstream raw materials:

ethyl 4-methyl-2-pyridinecarboxylate

4-methylpicolinic acid

2,4-lutidine

Downstream raw materials:

7-[(2,4-dichloro-3-fluorophenyl)carbonyl]-3-(4-methyl-2-pyridinyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine

Refernces

• 1、 -. "5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS". Page/Page column 74. . Retrieved 2010/11/17.