5-phenyl-4-N-phenylamino-7-(2,3-O-isopropylidene-α-L-lyxofuranosyl)pyrrolo[2,3-d]pyrimidine

Base Information

• Chemical Name: 5-phenyl-4-N-phenylamino-7-(2,3-O-isopropylidene-α-L-lyxofuranosyl)pyrrolo[2,3-d]pyrimidine
• CAS No.: 164514-37-8
• Molecular Formula: C₂₆H₂₆N₄O₄
• Molecular Weight: 458.517

Synonyms:5-phenyl-4-N-phenylamino-7-(2,3-O-isopropylidene-α-L-lyxofuranosyl)pyrrolo[2,3-d]pyrimidine

Chemical Property of 5-phenyl-4-N-phenylamino-7-(2,3-O-isopropylidene-α-L-lyxofuranosyl)pyrrolo[2,3-d]pyrimidine

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

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Technology Process of 5-phenyl-4-N-phenylamino-7-(2,3-O-isopropylidene-α-L-lyxofuranosyl)pyrrolo[2,3-d]pyrimidine

There total 3 articles about 5-phenyl-4-N-phenylamino-7-(2,3-O-isopropylidene-α-L-lyxofuranosyl)pyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

{7-[6-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-phenyl-amine (624727-85-1) → 5-phenyl-4-N-phenylamino-7-(2,3-O-isopropylidene-α-L-lyxofuranosyl)pyrrolo[2,3-d]pyrimidine (164514-37-8)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran;

DOI:10.1021/jm030230z

Reference yield:

4-N-phenylamino-5-phenylpyrrolo[2,3-d]pyrimidine (186393-51-1) → 5-phenyl-4-N-phenylamino-7-(2,3-O-isopropylidene-α-L-lyxofuranosyl)pyrrolo[2,3-d]pyrimidine (164514-37-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 3.54 g / KOH; TDA-1 / toluene / 20 °C

2: 79 percent / Bu₄NF / tetrahydrofuran

With potassium hydroxide; tetrabutyl ammonium fluoride; In tetrahydrofuran; toluene;

DOI:10.1021/jm030230z

Reference yield:

5-O-tert-butyldimethylsilyl-2,3-O-isopropylidene-L-lyxofuranosyl chloride → 5-phenyl-4-N-phenylamino-7-(2,3-O-isopropylidene-α-L-lyxofuranosyl)pyrrolo[2,3-d]pyrimidine (164514-37-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 3.54 g / KOH; TDA-1 / toluene / 20 °C

2: 79 percent / Bu₄NF / tetrahydrofuran

With potassium hydroxide; tetrabutyl ammonium fluoride; In tetrahydrofuran; toluene;

DOI:10.1021/jm030230z

upstream raw materials:

{7-[6-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-phenyl-amine

4-N-phenylamino-5-phenylpyrrolo[2,3-d]pyrimidine

Downstream raw materials:

5-phenyl-4-N-phenylamino-7-(5-amino-5-deoxy-2,3-O-isopropylidene-α-L-lyxofuranosyl)pyrrolo[2,3-d]pyrimidine

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