Bicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile, 4-hydroxy- (9CI)

Base Information

Chemical Name:Bicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile, 4-hydroxy- (9CI)
CAS No.:242473-47-8
Molecular Formula:C₉H₇NO
Molecular Weight:145.161
Hs Code.:
Mol file:242473-47-8.mol

Synonyms:Bicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile, 4-hydroxy- (9CI)

Suppliers and Price of Bicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile, 4-hydroxy- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of Bicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile, 4-hydroxy- (9CI)

Chemical Property:

Boiling Point:358.9±42.0 °C(Predicted)
PKA:9.94±0.40(Predicted)
Density:1.29±0.1 g/cm3(Predicted)

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Bicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile, 4-hydroxy- (9CI)

There total 1 articles about Bicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile, 4-hydroxy- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1199-31-1
1-cyano-5-methoxybenzocyclobutane

: 242473-47-8
5-hydroxybenzocyclobutene-1-carbonitrile

Guidance literature:: With trimethylsilyl iodide; In acetonitrile; for 18h; Heating;
DOI:10.1016/j.bmc.2006.09.046

Reference yield:

: 242473-47-8
5-hydroxybenzocyclobutene-1-carbonitrile

: 242473-25-2
1-Aminomethyl-1-(1-hydroxycyclohex-1-yl)-5-hydroxybenzocyclobutane

Guidance literature:

Reference yield:

: 242473-47-8
5-hydroxybenzocyclobutene-1-carbonitrile

: C₂₄H₂₁NO₄S

Guidance literature:: Multi-step reaction with 9 steps

1.1: toluene-4-sulfonic acid; N-iodo-succinimide / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.5 h / -78 - 0 °C / Inert atmosphere

2.2: 2 h / -78 - 20 °C

3.1: 1H-imidazole / N,N-dimethyl-formamide / 6 h / 0 - 20 °C / Inert atmosphere

4.1: pyridinium p-toluenesulfonate / ethanol / 3 h / Inert atmosphere; Reflux

5.1: dipyridinium dichromate / dichloromethane / 3 h / 20 °C / Inert atmosphere; Molecular sieve

6.1: toluene-4-sulfonic acid / benzene / 22 h / 20 °C / Inert atmosphere; Dean-Stark; Reflux

7.1: 1,2-dichloro-benzene / 2 h / Inert atmosphere; Reflux

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

9.1: 2-(hydroxymethyl)-2-methylpropane-1,3-diol; copper(l) iodide; caesium carbonate / N,N-dimethyl-formamide; 1,4-dioxane / 1.5 h / 20 - 110 °C / Inert atmosphere

With 1H-imidazole; N-iodo-succinimide; copper(l) iodide; dipyridinium dichromate; n-butyllithium; 2-(hydroxymethyl)-2-methylpropane-1,3-diol; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; caesium carbonate; toluene-4-sulfonic acid; diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; 1,2-dichloro-benzene; benzene;
DOI:10.1016/j.bmc.2013.05.059