(S)-Pyrrolidine-1,2-dicarboxylic acid 2-[(2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester 1-[1-(3,5-dimethoxy-phenyl)-1-methyl-ethyl] ester

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Chemical Name:(S)-Pyrrolidine-1,2-dicarboxylic acid 2-[(2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester 1-[1-(3,5-dimethoxy-phenyl)-1-methyl-ethyl] ester
CAS No.:192070-15-8
Molecular Formula:C₄₃H₅₃N₃O₁₀Si
Molecular Weight:799.993
Hs Code.:

(S)-Pyrrolidine-1,2-dicarboxylic acid 2-[(2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester 1-[1-(3,5-dimethoxy-phenyl)-1-methyl-ethyl] ester

Synonyms:(S)-Pyrrolidine-1,2-dicarboxylic acid 2-[(2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester 1-[1-(3,5-dimethoxy-phenyl)-1-methyl-ethyl] ester

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Chemical Property of (S)-Pyrrolidine-1,2-dicarboxylic acid 2-[(2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester 1-[1-(3,5-dimethoxy-phenyl)-1-methyl-ethyl] ester

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Technology Process of (S)-Pyrrolidine-1,2-dicarboxylic acid 2-[(2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester 1-[1-(3,5-dimethoxy-phenyl)-1-methyl-ethyl] ester

There total 1 articles about (S)-Pyrrolidine-1,2-dicarboxylic acid 2-[(2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester 1-[1-(3,5-dimethoxy-phenyl)-1-methyl-ethyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 101527-40-6
5'-O-tert-butyldiphenylsilylthymidine

: N-(α,α-dimethyl-3,5-dimethoxybenzyloxycarbonyl)-L-proline

: 192070-15-8
(S)-Pyrrolidine-1,2-dicarboxylic acid 2-[(2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester 1-[1-(3,5-dimethoxy-phenyl)-1-methyl-ethyl] ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 25 ℃; for 12h;
DOI:10.1021/jo9702608

Reference yield: 97.0%

: 192070-15-8
(S)-Pyrrolidine-1,2-dicarboxylic acid 2-[(2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester 1-[1-(3,5-dimethoxy-phenyl)-1-methyl-ethyl] ester

: 192070-14-7
(S)-Pyrrolidine-2-carboxylic acid (2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 1h;
DOI:10.1021/jo9702608

Reference yield:

: 192070-15-8
(S)-Pyrrolidine-1,2-dicarboxylic acid 2-[(2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester 1-[1-(3,5-dimethoxy-phenyl)-1-methyl-ethyl] ester

: 192070-12-5
3'-O-{N_α-(3,4-dimethoxy-6-nitrobenzyloxycarbonyl)-N_ε-[5-(dimethylamino)-1-naphthalenesulfonyl]-L-lysine-L-proline}-5'O-(tert-butyldiphenylsilyl)thymidine

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / TFA / CH₂Cl₂ / 1 h / 25 °C

2: 89 percent / N-hydroxybenzotriazole, N-methylmorpholine, 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 12 h / 0 - 25 °C

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jo9702608