Multi-step reaction with 7 steps
1.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 20 °C
1.2: 18 h / 20 °C
2.1: 4 h / 20 °C
3.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 - 20 °C
4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
5.1: sodium carbonate / dimethyl sulfoxide / 48 h / 120 °C
6.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 18 h / 2068.65 Torr
7.1: sodium t-butanolate / DavePhos; palladium diacetate / toluene / 110 °C / Inert atmosphere; Sealed tube
With
hydrogenchloride; hydrogen; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hexamethyldisilazane; sodium t-butanolate;
palladium 10% on activated carbon; palladium diacetate; DavePhos;
In
tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;