7-chloro-5-[[(2,3-difluorophenyl)methyl]thio]-3-(tetrahydro-2H-pyran-2-yl)-[1,3]-thiazolo[4,5-d]-pyrimidin-2(3H)-one

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Chemical Name:7-chloro-5-[[(2,3-difluorophenyl)methyl]thio]-3-(tetrahydro-2H-pyran-2-yl)-[1,3]-thiazolo[4,5-d]-pyrimidin-2(3H)-one
CAS No.:893433-57-3
Molecular Formula:C₁₇H₁₄ClF₂N₃O₂S₂
Molecular Weight:429.899
Hs Code.:

Synonyms:7-chloro-5-[[(2,3-difluorophenyl)methyl]thio]-3-(tetrahydro-2H-pyran-2-yl)-[1,3]-thiazolo[4,5-d]-pyrimidin-2(3H)-one

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Chemical Property of 7-chloro-5-[[(2,3-difluorophenyl)methyl]thio]-3-(tetrahydro-2H-pyran-2-yl)-[1,3]-thiazolo[4,5-d]-pyrimidin-2(3H)-one

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Technology Process of 7-chloro-5-[[(2,3-difluorophenyl)methyl]thio]-3-(tetrahydro-2H-pyran-2-yl)-[1,3]-thiazolo[4,5-d]-pyrimidin-2(3H)-one

There total 1 articles about 7-chloro-5-[[(2,3-difluorophenyl)methyl]thio]-3-(tetrahydro-2H-pyran-2-yl)-[1,3]-thiazolo[4,5-d]-pyrimidin-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 333743-70-7
7-chloro-5-[[(2,3-difluorophenyl)methyl]thio][1,3]thiazolo[4,5-d]-pyrimidin-2(3H)-one

: 893433-57-3
7-chloro-5-[[(2,3-difluorophenyl)methyl]thio]-3-(tetrahydro-2H-pyran-2-yl)-[1,3]-thiazolo[4,5-d]-pyrimidin-2(3H)-one

Guidance literature:: 3,4-dihydro-2H-pyran; 7-chloro-5-[[(2,3-difluorophenyl)methyl]thio][1,3]thiazolo[4,5-d]-pyrimidin-2(3H)-one; With toluene-4-sulfonic acid; In toluene; at 20 - 60 ℃; for 3h;

With sodium hydrogencarbonate; In water; toluene; at 20 ℃; for 1h;

Reference yield:

: (D)-alaninol

: 893433-57-3
7-chloro-5-[[(2,3-difluorophenyl)methyl]thio]-3-(tetrahydro-2H-pyran-2-yl)-[1,3]-thiazolo[4,5-d]-pyrimidin-2(3H)-one

: 855476-59-4
5-[[(2,3-dinuorophenyl)methyl]thio]-7-[[(1R)-2-hydroxy-1-methylethyl]amino]-3-(tetrahydro-2H-pyran-2-yl)-thiazolo[4,5-d]pyrimidin-2-(3H)-one

Guidance literature:: (D)-alaninol; 7-chloro-5-[[(2,3-difluorophenyl)methyl]thio]-3-(tetrahydro-2H-pyran-2-yl)-[1,3]-thiazolo[4,5-d]-pyrimidin-2(3H)-one; With sodium carbonate; In tetrahydrofuran; toluene; at 60 - 65 ℃; for 25.5h;

In tetrahydrofuran; water; toluene; at 60 ℃; for 1h;

Reference yield:

: 893433-57-3
7-chloro-5-[[(2,3-difluorophenyl)methyl]thio]-3-(tetrahydro-2H-pyran-2-yl)-[1,3]-thiazolo[4,5-d]-pyrimidin-2(3H)-one

: 687-47-8
(S)-Ethyl lactate

: 893433-58-4
ethyl (2R)-2-{[5-[(2,3-difluorobenzyl)thio]-2-oxo-3-(tetrahydro-2H-pyran-2-yl)-2,3-dihydro[1,3]thiazolo[4,5-d]pyrimidin-7-yl]oxy}-propanoate

Guidance literature:: 7-chloro-5-[[(2,3-difluorophenyl)methyl]thio]-3-(tetrahydro-2H-pyran-2-yl)-[1,3]-thiazolo[4,5-d]-pyrimidin-2(3H)-one; (S)-Ethyl lactate; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 18h;

With ammonium chloride; In tetrahydrofuran; water;