2-oxo-7-syn-<3αβ-hydroxy-4-(3-chlorophenoxy)-1-trans-butenyl>-8-anti-hydroxy-cis-bicyclo<4.3.0>nonan-3-ol

Base Information

Chemical Name:2-oxo-7-syn-<3αβ-hydroxy-4-(3-chlorophenoxy)-1-trans-butenyl>-8-anti-hydroxy-cis-bicyclo<4.3.0>nonan-3-ol
CAS No.:67039-85-4
Molecular Formula:C₁₈H₂₃ClO₅
Molecular Weight:354.831
Hs Code.:

Synonyms:2-oxo-7-syn-<3αβ-hydroxy-4-(3-chlorophenoxy)-1-trans-butenyl>-8-anti-hydroxy-cis-bicyclo<4.3.0>nonan-3-ol

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Chemical Property of 2-oxo-7-syn-<3αβ-hydroxy-4-(3-chlorophenoxy)-1-trans-butenyl>-8-anti-hydroxy-cis-bicyclo<4.3.0>nonan-3-ol

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Technology Process of 2-oxo-7-syn-<3αβ-hydroxy-4-(3-chlorophenoxy)-1-trans-butenyl>-8-anti-hydroxy-cis-bicyclo<4.3.0>nonan-3-ol

There total 1 articles about 2-oxo-7-syn-<3αβ-hydroxy-4-(3-chlorophenoxy)-1-trans-butenyl>-8-anti-hydroxy-cis-bicyclo<4.3.0>nonan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 67039-82-1
2-syn-(3-methoxy-trans,cis-propenyl)-3-anti-<3αβ-(tetrahydropyran-2-yloxy)-4-(3-chlorophenoxy)-1-trans-butenyl>-4-syn-(tetrahydropyran-2-yloxy)cyclopentan-1-ol

: 67039-85-4
2-oxo-7-syn-<3αβ-hydroxy-4-(3-chlorophenoxy)-1-trans-butenyl>-8-anti-hydroxy-cis-bicyclo<4.3.0>nonan-3-ol

Guidance literature:: With acetic acid; In tetrahydrofuran; at 60 ℃; for 3h;
DOI:10.1021/jm00179a011

Reference yield:

: 67039-85-4
2-oxo-7-syn-<3αβ-hydroxy-4-(3-chlorophenoxy)-1-trans-butenyl>-8-anti-hydroxy-cis-bicyclo<4.3.0>nonan-3-ol

: 73319-03-6
3-{(1R,2R,3R,5S)-2-[(E)-4-(3-Chloro-phenoxy)-3-hydroxy-but-1-enyl]-3,5-dihydroxy-cyclopentyl}-propionic acid

Guidance literature:: With sodium hydroxide; silver nitrate; In methanol; at 25 ℃; for 2h;
DOI:10.1021/jm00179a011

Reference yield:

: 67039-85-4
2-oxo-7-syn-<3αβ-hydroxy-4-(3-chlorophenoxy)-1-trans-butenyl>-8-anti-hydroxy-cis-bicyclo<4.3.0>nonan-3-ol

: 67039-91-2
1-syn,4-syn-bis(tetrahydropyran-2-yloxy)-2-syn-<2-carbomethoxy-2-(phenylselenyl)ethyl>-3-anti-<3αβ-(tetrahydrppyran-2-yloxy)-4-(3-chlorophenoxy)-1-trans-butenyl>cyclopentane

Guidance literature:: Multi-step reaction with 4 steps

1: aq. AgNO₃, aq. NaOH / methanol / 2 h / 25 °C

2: diethyl ether; ethyl acetate / 5 °C

3: p-toluenesulfonic acid / CH₂Cl₂ / 0.25 h / 10 °C

4: 1.) LDA / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, a) -78 deg C, 40 min, b) 5 deg C, 30 min

With sodium hydroxide; toluene-4-sulfonic acid; silver nitrate; lithium diisopropyl amide; In methanol; diethyl ether; dichloromethane; ethyl acetate;
DOI:10.1021/jm00179a011