((4R,6S)-6-{(4-[3-chloro-4-(3-fluorobenzyloxy)phenylamino]-quinazolin-6-yl)oxymethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester

Base Information

• Chemical Name: ((4R,6S)-6-{(4-[3-chloro-4-(3-fluorobenzyloxy)phenylamino]-quinazolin-6-yl)oxymethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester
• CAS No.: 867150-32-1
• Molecular Formula: C₃₄H₃₇ClFN₃O₆
• Molecular Weight: 638.136

Synonyms:((4R,6S)-6-{(4-[3-chloro-4-(3-fluorobenzyloxy)phenylamino]-quinazolin-6-yl)oxymethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester

Chemical Property of ((4R,6S)-6-{(4-[3-chloro-4-(3-fluorobenzyloxy)phenylamino]-quinazolin-6-yl)oxymethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester

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Technology Process of ((4R,6S)-6-{(4-[3-chloro-4-(3-fluorobenzyloxy)phenylamino]-quinazolin-6-yl)oxymethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester

There total 1 articles about ((4R,6S)-6-{(4-[3-chloro-4-(3-fluorobenzyloxy)phenylamino]-quinazolin-6-yl)oxymethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

((4R,6S)-2,2-dimethyl-6-trifluoromethanesulfonyloxymethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester (477873-79-3) + 4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-ol (230955-55-2) → ((4R,6S)-6-{(4-[3-chloro-4-(3-fluorobenzyloxy)phenylamino]-quinazolin-6-yl)oxymethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester (867150-32-1)

Guidance literature:

With caesium carbonate; In ISOPROPYLAMIDE; at 20 ℃; for 18h;

Reference yield:

((4R,6S)-6-{(4-[3-chloro-4-(3-fluorobenzyloxy)phenylamino]-quinazolin-6-yl)oxymethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester (867150-32-1) → (4R,6S)-6-{(4-[3-chloro-4-(3-fluorobenzyloxy)phenylamino]-quinazolin-6-yl)oxymethyl}-4-hydroxy-tetrahydropyran-2-one

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield:

((4R,6S)-6-{(4-[3-chloro-4-(3-fluorobenzyloxy)phenylamino]-quinazolin-6-yl)oxymethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester (867150-32-1) → (3R,5S)-6-{(4-[3-chloro-4-(3-fluorobenzyloxy)phenylamino]-quinazolin-6-yl)oxy}-3,5-dihydroxyhexanoic acid tert-butyl ester

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; for 3h;

upstream raw materials:

((4R,6S)-2,2-dimethyl-6-trifluoromethanesulfonyloxymethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester

4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-ol

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