methyl 5-(4-fluorophenyl)-1-methyl-6-oxo-2,3,5,6-tetrahydro-1H-pyrido[2,3-b][1,4]oxazine-7-formate

Base Information

Chemical Name:methyl 5-(4-fluorophenyl)-1-methyl-6-oxo-2,3,5,6-tetrahydro-1H-pyrido[2,3-b][1,4]oxazine-7-formate
CAS No.:1415798-06-9
Molecular Formula:C₁₆H₁₅FN₂O₄
Molecular Weight:318.305
Hs Code.:

Synonyms:methyl 5-(4-fluorophenyl)-1-methyl-6-oxo-2,3,5,6-tetrahydro-1H-pyrido[2,3-b][1,4]oxazine-7-formate

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Chemical Property of methyl 5-(4-fluorophenyl)-1-methyl-6-oxo-2,3,5,6-tetrahydro-1H-pyrido[2,3-b][1,4]oxazine-7-formate

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Technology Process of methyl 5-(4-fluorophenyl)-1-methyl-6-oxo-2,3,5,6-tetrahydro-1H-pyrido[2,3-b][1,4]oxazine-7-formate

There total 6 articles about methyl 5-(4-fluorophenyl)-1-methyl-6-oxo-2,3,5,6-tetrahydro-1H-pyrido[2,3-b][1,4]oxazine-7-formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1415798-05-8
methyl 1-methyl-6-oxo-2,3,5,6-tetrahydro-1H-pyrido[2,3-b][1,4]oxazine-7-formate

: 1765-93-1
4-fluoroboronic acid

: 1415798-06-9
methyl 5-(4-fluorophenyl)-1-methyl-6-oxo-2,3,5,6-tetrahydro-1H-pyrido[2,3-b][1,4]oxazine-7-formate

Guidance literature:: With pyridine; copper(l) iodide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In acetonitrile; at 40 ℃; for 60h;

Reference yield:

: 1415798-04-7
methyl 1-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-formate

: 1415798-06-9
methyl 5-(4-fluorophenyl)-1-methyl-6-oxo-2,3,5,6-tetrahydro-1H-pyrido[2,3-b][1,4]oxazine-7-formate

Guidance literature:: Multi-step reaction with 2 steps

1: p-chloroperbenzoic acid / dichloromethane / 21 h / 20 °C

2: pyridine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; copper(l) iodide / acetonitrile / 60 h / 40 °C

With pyridine; copper(l) iodide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; p-chloroperbenzoic acid; In dichloromethane; acetonitrile;

Reference yield:

: 924279-03-8
methyl 6-(2-methoxy-2-carbonylethoxy)-5-nitronicotinate

: 1415798-06-9
methyl 5-(4-fluorophenyl)-1-methyl-6-oxo-2,3,5,6-tetrahydro-1H-pyrido[2,3-b][1,4]oxazine-7-formate

Guidance literature:: Multi-step reaction with 5 steps

1.1: iron; acetic acid / 2 h / 70 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

2.2: 18 h / 20 °C / Inert atmosphere

3.1: dimethylsulfide borane complex / tetrahydrofuran / 2.5 h / 0 - 40 °C / Inert atmosphere

3.2: 1 h / Inert atmosphere; Reflux

4.1: p-chloroperbenzoic acid / dichloromethane / 21 h / 20 °C

5.1: pyridine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; copper(l) iodide / acetonitrile / 60 h / 40 °C

With pyridine; copper(l) iodide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; dimethylsulfide borane complex; p-chloroperbenzoic acid; iron; sodium hydride; acetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;