(R)-1-(2,2-diethoxyethyl)-1′-(p-tolyl)-1′H-spiro[indoline-3,4′-pyrimidine]-2,2′,6′(3′H,5′H)-trione

Base Information

Chemical Name:(R)-1-(2,2-diethoxyethyl)-1′-(p-tolyl)-1′H-spiro[indoline-3,4′-pyrimidine]-2,2′,6′(3′H,5′H)-trione
CAS No.:1188395-65-4
Molecular Formula:C₂₄H₂₇N₃O₅
Molecular Weight:437.495
Hs Code.:

Synonyms:(R)-1-(2,2-diethoxyethyl)-1′-(p-tolyl)-1′H-spiro[indoline-3,4′-pyrimidine]-2,2′,6′(3′H,5′H)-trione

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Chemical Property of (R)-1-(2,2-diethoxyethyl)-1′-(p-tolyl)-1′H-spiro[indoline-3,4′-pyrimidine]-2,2′,6′(3′H,5′H)-trione

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Technology Process of (R)-1-(2,2-diethoxyethyl)-1′-(p-tolyl)-1′H-spiro[indoline-3,4′-pyrimidine]-2,2′,6′(3′H,5′H)-trione

There total 6 articles about (R)-1-(2,2-diethoxyethyl)-1′-(p-tolyl)-1′H-spiro[indoline-3,4′-pyrimidine]-2,2′,6′(3′H,5′H)-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: (R)-S-phenyl 2-(2-oxo-3-(3-(p-tolyl)ureido)indolin-3-yl)ethanethioate

: 2032-35-1
Bromoacetaldehyde diethyl acetal

: 1188395-65-4
(R)-1-(2,2-diethoxyethyl)-1′-(p-tolyl)-1′H-spiro[indoline-3,4′-pyrimidine]-2,2′,6′(3′H,5′H)-trione

Guidance literature:: With potassium tert-butylate; tetra-(n-butyl)ammonium iodide; In N,N-dimethyl acetamide; at 80 ℃; for 3h; Inert atmosphere;
DOI:10.1039/c7ob02407j

Reference yield:

: 1188395-64-3
(R)-methyl 2-(2-oxo-3-(3-p-tolylureido)indolin-3-yl)acetate

: 2032-35-1
Bromoacetaldehyde diethyl acetal

: 1188395-65-4
(R)-1-(2,2-diethoxyethyl)-1′-(p-tolyl)-1′H-spiro[indoline-3,4′-pyrimidine]-2,2′,6′(3′H,5′H)-trione

Guidance literature:: With potassium tert-butylate; tetra-(n-butyl)ammonium iodide; In N,N-dimethyl acetamide; at 80 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jo901352u

Reference yield:

: S-phenyl 2-(2-oxo-3-(3-(p-tolyl)ureido)indolin-3-yl)ethanethioate

: 2032-35-1
Bromoacetaldehyde diethyl acetal

: 1188395-65-4
(R)-1-(2,2-diethoxyethyl)-1′-(p-tolyl)-1′H-spiro[indoline-3,4′-pyrimidine]-2,2′,6′(3′H,5′H)-trione

: 1-(2,2-diethoxyethyl)-1'-(p-tolyl)-1'H-spiro[indoline-3,4'-pyrimidine]-2,2',6'(3'H,5'H)-trione

Guidance literature:: With N,N-dimethyl acetamide; potassium tert-butylate; tetra-(n-butyl)ammonium iodide; at 80 ℃; for 4h; Overall yield = 59 %; Overall yield = 112 mg; Inert atmosphere; Schlenk technique;
DOI:10.1021/acs.orglett.8b02306