(9-{(3aR,4R,6R,6aR)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-9H-purin-6-yl)-carbamic acid benzyl ester

Base Information

Chemical Name:(9-{(3aR,4R,6R,6aR)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-9H-purin-6-yl)-carbamic acid benzyl ester
CAS No.:192052-71-4
Molecular Formula:C₄₂H₄₁N₅O₈
Molecular Weight:743.816
Hs Code.:

(9-{(3aR,4R,6R,6aR)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-9H-purin-6-yl)-carbamic acid benzyl ester

Synonyms:(9-{(3aR,4R,6R,6aR)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-9H-purin-6-yl)-carbamic acid benzyl ester

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Chemical Property of (9-{(3aR,4R,6R,6aR)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-9H-purin-6-yl)-carbamic acid benzyl ester

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Technology Process of (9-{(3aR,4R,6R,6aR)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-9H-purin-6-yl)-carbamic acid benzyl ester

There total 1 articles about (9-{(3aR,4R,6R,6aR)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-9H-purin-6-yl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 59577-41-2
1-benzyloxycarbonyloxy-1H-benzotriazole

: 68074-34-0
O^5'-(4,4'-dimethoxy-trityl)-O^2'_,O3'-isopropylidene-adenosine

: 192052-71-4
(9-{(3aR,4R,6R,6aR)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-9H-purin-6-yl)-carbamic acid benzyl ester

Guidance literature:: With tert.-butyl lithium; 1.) -78 deg C, 10 min; 2.) -78 deg C, 5 min, then room temp., 15 min;
DOI:10.1002/hlca.19970800304

Reference yield: 90.0%

: 192052-71-4
(9-{(3aR,4R,6R,6aR)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-9H-purin-6-yl)-carbamic acid benzyl ester

: 192052-69-0
N⁶-benzoyl-2',3'-isopropylidene adenosine

Guidance literature:: With dichloro-acetic acid; pyrrole; In dichloromethane; for 0.0333333h; Ambient temperature;
DOI:10.1002/hlca.19970800304

Reference yield:

: 192052-71-4
(9-{(3aR,4R,6R,6aR)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-9H-purin-6-yl)-carbamic acid benzyl ester

: Hexanedioic acid 4-{(S)-2-((S)-2-amino-4-carboxy-butyrylamino)-2-[(S)-3-methyl-1-(morpholine-4-carbonyl)-butylcarbamoyl]-ethyl}-phenyl ester (2R,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / 1H-pyrrole, 5percent CHCl₂COOH / CH₂Cl₂ / 0.03 h / Ambient temperature

2: 64 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 21 h

3: 1.) 1-chloro-N,N,2-trimethylprop-1-en-1-amine; 2.) (i-Pr)2EtN / 1.) CH₂Cl₂, 15 min; 2.) CH₂Cl₂, 0-5 deg C, then room temp., 16 h, then 40 deeg C, 5 h

4: H₂ / 10percent Pd/C / dioxane; H₂O / 3 h / 760 Torr / Ambient temperature

5: CF₃COOH / 0.5 h / Ambient temperature

With dichloro-acetic acid; dmap; pyrrole; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In 1,4-dioxane; dichloromethane; water;
DOI:10.1002/hlca.19970800304