4-benzylidene-2-methyl-3,4-dihydro-2H-benzo[e][1,2]thiazine-1,1-dioxide

Base Information

Chemical Name:4-benzylidene-2-methyl-3,4-dihydro-2H-benzo[e][1,2]thiazine-1,1-dioxide
CAS No.:1242459-15-9
Molecular Formula:C₁₆H₁₅NO₂S
Molecular Weight:285.367
Hs Code.:

Synonyms:4-benzylidene-2-methyl-3,4-dihydro-2H-benzo[e][1,2]thiazine-1,1-dioxide

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Chemical Property of 4-benzylidene-2-methyl-3,4-dihydro-2H-benzo[e][1,2]thiazine-1,1-dioxide

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Technology Process of 4-benzylidene-2-methyl-3,4-dihydro-2H-benzo[e][1,2]thiazine-1,1-dioxide

There total 7 articles about 4-benzylidene-2-methyl-3,4-dihydro-2H-benzo[e][1,2]thiazine-1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-bromo-N-methyl-N-(3-phenylallyl)benzenesulfonamide

: 1242459-15-9
4-benzylidene-2-methyl-3,4-dihydro-2H-benzo[e][1,2]thiazine-1,1-dioxide

Guidance literature:: With palladium diacetate; triethylamine; diisopropylamine; In toluene; at 100 - 120 ℃; for 24h; Inert atmosphere;

Reference yield:

: 2327-99-3
1-phenylpropadiene

: 120641-02-3
2-methyl-2H-benzo[e][1,2,3,4]thiatriazine 1,1-dioxide

: 1242459-15-9
4-benzylidene-2-methyl-3,4-dihydro-2H-benzo[e][1,2]thiazine-1,1-dioxide

: C₁₆H₁₅NO₂S

: C₁₆H₁₅NO₂S

Guidance literature:: With (R)-1-(2-(diphenylphosphanyl)naphthalen-1-yl)isoquinoline; bis(1,5-cyclooctadiene)nickel⁽⁰⁾; In tetrahydrofuran; acetonitrile; at 60 ℃; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1002/anie.201001918

Reference yield:

: 88-21-1
2-amino-1-benzenesulfonic acid

: 1242459-15-9
4-benzylidene-2-methyl-3,4-dihydro-2H-benzo[e][1,2]thiazine-1,1-dioxide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium nitrite; potassium bromide; hydrogenchloride

2.1: sodium hydroxide

3.1: phosphorus pentachloride / neat (no solvent)

4.1: triethylamine / dichloromethane / 10 h / 20 °C / Cooling with ice

5.1: sodium hydride / N,N-dimethyl-formamide; hexane; mineral oil / 0.5 h / 20 °C

5.2: 20 °C

6.1: triethylamine; palladium diacetate; diisopropylamine / toluene / 24 h / 100 - 120 °C / Inert atmosphere

With hydrogenchloride; phosphorus pentachloride; palladium diacetate; sodium hydride; triethylamine; diisopropylamine; potassium bromide; sodium hydroxide; sodium nitrite; In hexane; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil; 6.1: |Heck Reaction;