5,7-Di-tert-butyl-2-(hydroxy-phenyl-methyl)-1-oxa-spiro[2.5]octa-4,7-dien-6-one

Base Information

Chemical Name:5,7-Di-tert-butyl-2-(hydroxy-phenyl-methyl)-1-oxa-spiro[2.5]octa-4,7-dien-6-one
CAS No.:102519-91-5
Molecular Formula:C₂₂H₂₈O₃
Molecular Weight:340.463
Hs Code.:

Synonyms:5,7-Di-tert-butyl-2-(hydroxy-phenyl-methyl)-1-oxa-spiro[2.5]octa-4,7-dien-6-one

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Chemical Property of 5,7-Di-tert-butyl-2-(hydroxy-phenyl-methyl)-1-oxa-spiro[2.5]octa-4,7-dien-6-one

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Technology Process of 5,7-Di-tert-butyl-2-(hydroxy-phenyl-methyl)-1-oxa-spiro[2.5]octa-4,7-dien-6-one

There total 6 articles about 5,7-Di-tert-butyl-2-(hydroxy-phenyl-methyl)-1-oxa-spiro[2.5]octa-4,7-dien-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 21449-69-4
(E)-2,6-di-tert-butyl-4-styrylphenol

: 102519-91-5
5,7-Di-tert-butyl-2-(hydroxy-phenyl-methyl)-1-oxa-spiro[2.5]octa-4,7-dien-6-one

: 1620-98-0
3,5-di-t-butyl-4-hydroxybenzaldehyde

Guidance literature:: With potassium tert-butylate; oxygen; In hexane; tert-butyl alcohol; for 0.5h;
DOI:10.1021/jo00362a018

Reference yield:

: 20017-35-0
1-(3,5-Di-tert-butyl-4-hydroxyphenyl)-1-propanol

: 102519-91-5
5,7-Di-tert-butyl-2-(hydroxy-phenyl-methyl)-1-oxa-spiro[2.5]octa-4,7-dien-6-one

Guidance literature:: Multi-step reaction with 8 steps

1: CH₃COOH / 0.17 h / Heating

2: 43 percent / t-BuOK, O₂ / 2-methyl-propan-2-ol; hexane / 0.5 h / 0 °C

3: diethyl ether / 2.5 h / Heating

4: CH₃COOH / 0.17 h / Heating

5: 80 percent Spectr_. / t-BuOK, O₂ / 2-methyl-propan-2-ol; hexane / 0.5 h / 0 °C

6: diethyl ether / 2.5 h / Heating

7: CH₃COOH / 0.17 h / Heating

8: 20 percent / t-BuOK, O₂ / 2-methyl-propan-2-ol; hexane / 0.5 h

With potassium tert-butylate; oxygen; acetic acid; In diethyl ether; hexane; tert-butyl alcohol;
DOI:10.1021/jo00362a018

Reference yield:

: 20359-84-6
2,6-di-tert-butyl-4-(1-hydroxy-2-methylpropyl)phenol

: 102519-91-5
5,7-Di-tert-butyl-2-(hydroxy-phenyl-methyl)-1-oxa-spiro[2.5]octa-4,7-dien-6-one

Guidance literature:: Multi-step reaction with 8 steps

1: CH₃COOH / 0.17 h / Heating

2: 80 percent Spectr_. / t-BuOK, O₂ / 2-methyl-propan-2-ol; hexane / 0.5 h / 0 °C

3: diethyl ether / 2.5 h / Heating

4: CH₃COOH / 0.17 h / Heating

5: 43 percent / t-BuOK, O₂ / 2-methyl-propan-2-ol; hexane / 0.5 h / 0 °C

6: diethyl ether / 2.5 h / Heating

7: CH₃COOH / 0.17 h / Heating

8: 20 percent / t-BuOK, O₂ / 2-methyl-propan-2-ol; hexane / 0.5 h

With potassium tert-butylate; oxygen; acetic acid; In diethyl ether; hexane; tert-butyl alcohol;
DOI:10.1021/jo00362a018