ethyl (2Z)-3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-2-methylacrylate

Base Information

• Chemical Name: ethyl (2Z)-3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-2-methylacrylate
• CAS No.: 1379461-37-6
• Molecular Formula: C₂₁H₂₁ClF₃NO₅
• Molecular Weight: 459.85

Synonyms:ethyl (2Z)-3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-2-methylacrylate

Chemical Property of ethyl (2Z)-3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-2-methylacrylate

Chemical Property:

Purity/Quality:

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Technology Process of ethyl (2Z)-3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-2-methylacrylate

There total 2 articles about ethyl (2Z)-3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-2-methylacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methoxy-ethanol (109-86-4,95507-80-5) + ethyl 3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-hydroxyphenyl)-2-methylacrylate → ethyl (2E)-3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-2-methylacrylate (926295-45-6) + ethyl (2Z)-3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-2-methylacrylate (1379461-37-6)

Guidance literature:

With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; at 50 ℃; for 0.0833333h;

DOI:10.1016/j.bmc.2012.03.036

Reference yield:

ethyl 3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(methoxymethoxy)phenyl]-2-methylacrylate → ethyl (2E)-3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-2-methylacrylate (926295-45-6) + ethyl (2Z)-3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-2-methylacrylate (1379461-37-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; water / acetone / 5 h / Reflux

2: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 0.08 h / 50 °C

With hydrogenchloride; tributylphosphine; water; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; acetone; 2: Mitsunobu reaction;

DOI:10.1016/j.bmc.2012.03.036

upstream raw materials:

2-methoxy-ethanol

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