5-((2-(4-(4-fluoropiperidin-4-yl)benzamide)pyridin-4-yl)oxy)-6-methoxy-N-methyl-1H-indole-1-carboxamide

Base Information

Chemical Name:5-((2-(4-(4-fluoropiperidin-4-yl)benzamide)pyridin-4-yl)oxy)-6-methoxy-N-methyl-1H-indole-1-carboxamide
CAS No.:1622204-06-1
Molecular Formula:C₂₈H₂₈FN₅O₄
Molecular Weight:517.56
Hs Code.:

Synonyms:5-((2-(4-(4-fluoropiperidin-4-yl)benzamide)pyridin-4-yl)oxy)-6-methoxy-N-methyl-1H-indole-1-carboxamide

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Chemical Property of 5-((2-(4-(4-fluoropiperidin-4-yl)benzamide)pyridin-4-yl)oxy)-6-methoxy-N-methyl-1H-indole-1-carboxamide

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Technology Process of 5-((2-(4-(4-fluoropiperidin-4-yl)benzamide)pyridin-4-yl)oxy)-6-methoxy-N-methyl-1H-indole-1-carboxamide

There total 16 articles about 5-((2-(4-(4-fluoropiperidin-4-yl)benzamide)pyridin-4-yl)oxy)-6-methoxy-N-methyl-1H-indole-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1622205-27-9
5-((2-aminopyridin-4-yl)oxy)-6-methoxy-N-methyl-1H-indole-1-carboxamide

: 1622205-33-7
4-(1-(tert-butoxycarbonyl)-4-fluoropiperidin-4-yl)benzoic acid

: 1622204-06-1
5-((2-(4-(4-fluoropiperidin-4-yl)benzamide)pyridin-4-yl)oxy)-6-methoxy-N-methyl-1H-indole-1-carboxamide

Guidance literature:: 4-(1-(tert-butoxycarbonyl)-4-fluoropiperidin-4-yl)benzoic acid; With 1,2,3-Benzotriazole; thionyl chloride; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

5-((2-aminopyridin-4-yl)oxy)-6-methoxy-N-methyl-1H-indole-1-carboxamide; With dmap; triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 32664-14-5
2-(4-bromophenyl)-4,4-dimethyl-2-oxazoline

: 1622204-06-1
5-((2-(4-(4-fluoropiperidin-4-yl)benzamide)pyridin-4-yl)oxy)-6-methoxy-N-methyl-1H-indole-1-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: magnesium; iodine / tetrahydrofuran / 1 h / Reflux

1.2: 3 h / 20 °C / Reflux

2.1: sulfuric acid / 12 h / 90 °C

3.1: diethylamino-sulfur trifluoride / dichloromethane / 3 h / -78 - 20 °C / Inert atmosphere

4.1: carbonochloridic acid 1-chloro-ethyl ester / dichloromethane / 2 h / 20 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 1 h / 20 °C

6.1: methanol; sodium hydroxide / tetrahydrofuran / 4 h / 50 °C

7.1: 1,2,3-Benzotriazole; thionyl chloride / dichloromethane / 2 h / 20 °C / Inert atmosphere

7.2: 2 h / 20 °C

With methanol; 1,2,3-Benzotriazole; thionyl chloride; carbonochloridic acid 1-chloro-ethyl ester; diethylamino-sulfur trifluoride; sulfuric acid; iodine; magnesium; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 1622204-06-1
5-((2-(4-(4-fluoropiperidin-4-yl)benzamide)pyridin-4-yl)oxy)-6-methoxy-N-methyl-1H-indole-1-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: magnesium; iodine / tetrahydrofuran / 1 h / Reflux

1.2: 3 h / 20 °C / Reflux

2.1: sulfuric acid / 12 h / 90 °C

3.1: diethylamino-sulfur trifluoride / dichloromethane / 3 h / -78 - 20 °C / Inert atmosphere

4.1: carbonochloridic acid 1-chloro-ethyl ester / dichloromethane / 2 h / 20 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 1 h / 20 °C

6.1: methanol; sodium hydroxide / tetrahydrofuran / 4 h / 50 °C

7.1: 1,2,3-Benzotriazole; thionyl chloride / dichloromethane / 2 h / 20 °C / Inert atmosphere

7.2: 2 h / 20 °C

With methanol; 1,2,3-Benzotriazole; thionyl chloride; carbonochloridic acid 1-chloro-ethyl ester; diethylamino-sulfur trifluoride; sulfuric acid; iodine; magnesium; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane;