1-(2-fluoro-4-(4-(trifluoromethoxy)benzyl)phenyl)propan-1-ol

Base Information

• Chemical Name: 1-(2-fluoro-4-(4-(trifluoromethoxy)benzyl)phenyl)propan-1-ol
• CAS No.: 1375523-96-8
• Molecular Formula: C₁₇H₁₆F₄O₂
• Molecular Weight: 328.306
• Mol file: 1375523-96-8.mol

Synonyms:1-(2-fluoro-4-(4-(trifluoromethoxy)benzyl)phenyl)propan-1-ol

Chemical Property of 1-(2-fluoro-4-(4-(trifluoromethoxy)benzyl)phenyl)propan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-fluoro-4-(4-(trifluoromethoxy)benzyl)phenyl)propan-1-ol

There total 4 articles about 1-(2-fluoro-4-(4-(trifluoromethoxy)benzyl)phenyl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-fluoro-4-(4-(trifluoromethoxy)benzyl)benzaldehyde (1361005-62-0) + ethylmagnesium bromide (925-90-6) → 1-(2-fluoro-4-(4-(trifluoromethoxy)benzyl)phenyl)propan-1-ol (1375523-96-8)

Guidance literature:

In diethyl ether; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jm201179h

Reference yield: 88.0%

→ 1-(2-fluoro-4-(4-(trifluoromethoxy)benzyl)phenyl)propan-1-ol (1375523-96-8)

Guidance literature:

Reference yield:

3-fluoro-4-formylphenylboronic acid (248270-25-9) → 1-(2-fluoro-4-(4-(trifluoromethoxy)benzyl)phenyl)propan-1-ol (1375523-96-8)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / tetrahydrofuran; water / 5 h / 80 °C / Inert atmosphere

2: diethyl ether / 1 h / 0 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; diethyl ether; water; 2: Grignard reaction;

DOI:10.1021/jm201179h

upstream raw materials:

3-fluoro-4-formylphenylboronic acid

2-fluoro-4-(4-(trifluoromethoxy)benzyl)benzaldehyde

ethylmagnesium bromide

4-trifluoromethoxybenzyl bromide

Downstream raw materials:

7-chloro-2-(2-fluoro-4-(4-(trifluoromethoxy)benzyl)phenyl)-3-methylquinolin-4(1H)-one

1-(2-fluoro-4-(4-(trifluoromethoxy)benzyl)phenyl)propan-1-one