5-chloro-1-(4-chlorophenyl)-2-(2-methylprop-1-en-1-yl)-3-phenyl-1H-indene

Base Information

• Chemical Name: 5-chloro-1-(4-chlorophenyl)-2-(2-methylprop-1-en-1-yl)-3-phenyl-1H-indene
• CAS No.: 1333480-62-8
• Molecular Formula: C₂₅H₂₀Cl₂
• Molecular Weight: 391.34
• Mol file: 1333480-62-8.mol

Synonyms:5-chloro-1-(4-chlorophenyl)-2-(2-methylprop-1-en-1-yl)-3-phenyl-1H-indene

Chemical Property of 5-chloro-1-(4-chlorophenyl)-2-(2-methylprop-1-en-1-yl)-3-phenyl-1H-indene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-chloro-1-(4-chlorophenyl)-2-(2-methylprop-1-en-1-yl)-3-phenyl-1H-indene

There total 11 articles about 5-chloro-1-(4-chlorophenyl)-2-(2-methylprop-1-en-1-yl)-3-phenyl-1H-indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1'-(5-methyl-1-phenylhex-4-en-1-yne-3,3-diyl)bis(4-chlorobenzene) (1333480-53-7) → C25H20Cl2 (1333480-63-9) + 5-chloro-1-(4-chlorophenyl)-2-(2-methylprop-1-en-1-yl)-3-phenyl-1H-indene (1333480-62-8)

Guidance literature:

With Zeise's dimer; trans-4-Octene; In cyclohexane; at 70 - 120 ℃; for 24h; regioselective reaction; Inert atmosphere;

DOI:10.1021/ol202104c

Reference yield:

C24H20Cl2O2 → C25H20Cl2 (1333480-63-9) + 5-chloro-1-(4-chlorophenyl)-2-(2-methylprop-1-en-1-yl)-3-phenyl-1H-indene (1333480-62-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 2 h / 70 °C

2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 2 h / 0 - 20 °C / pH 7 / aq. phosphate buffer

3.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane

4.1: potassium hexamethylsilazane / toluene / 0.5 h / 0 °C

4.2: 6 h / -78 - 0 °C

5.1: Zeise's dimer; trans-4-Octene / cyclohexane / 24 h / 70 - 120 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Zeise's dimer; trans-4-Octene; potassium hexamethylsilazane; sodium hydrogencarbonate; Dess-Martin periodane; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; cyclohexane; N,N-dimethyl-formamide; toluene; 1.1: Sonogashira coupling / 4.1: Wittig reaction / 4.2: Wittig reaction;

DOI:10.1021/ol202104c

Reference yield:

C15H14Cl2O2 (86310-29-4) → C25H20Cl2 (1333480-63-9) + 5-chloro-1-(4-chlorophenyl)-2-(2-methylprop-1-en-1-yl)-3-phenyl-1H-indene (1333480-62-8)

Guidance literature:

Multi-step reaction with 10 steps

1.1: 10-camphorsufonic acid / dichloromethane / 2 h / 0 °C

2.1: diisobutylaluminium hydride / hexane; dichloromethane / -78 - 20 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C

4.1: triphenylphosphine / dichloromethane / 0.17 h / 0 °C

5.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / 0 °C

6.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 2 h / 70 °C

7.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 2 h / 0 - 20 °C / pH 7 / aq. phosphate buffer

8.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane

9.1: potassium hexamethylsilazane / toluene / 0.5 h / 0 °C

9.2: 6 h / -78 - 0 °C

10.1: Zeise's dimer; trans-4-Octene / cyclohexane / 24 h / 70 - 120 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; oxalyl dichloride; Zeise's dimer; trans-4-Octene; 10-camphorsufonic acid; potassium hexamethylsilazane; diisobutylaluminium hydride; sodium hydrogencarbonate; Dess-Martin periodane; dimethyl sulfoxide; triethylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; hexane; dichloromethane; cyclohexane; N,N-dimethyl-formamide; toluene; 6.1: Sonogashira coupling / 9.1: Wittig reaction / 9.2: Wittig reaction;

DOI:10.1021/ol202104c

upstream raw materials:

1,1'-(5-methyl-1-phenylhex-4-en-1-yne-3,3-diyl)bis(4-chlorobenzene)

C₁₅H₁₄Cl₂O₂

2,2-bis(4-chlorophenyl)acetaldehyde

Refernces