(2S,3R)-3-hydroxy-3-[(S)-1-(4-methoxybenzyl)-5-oxopyrrolidin-2-yl]-3-phenyl-2-(triethylsilyloxy)propanal

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Chemical Name:(2S,3R)-3-hydroxy-3-[(S)-1-(4-methoxybenzyl)-5-oxopyrrolidin-2-yl]-3-phenyl-2-(triethylsilyloxy)propanal
CAS No.:1034170-17-6
Molecular Formula:C₂₇H₃₇NO₅Si
Molecular Weight:483.68
Hs Code.:

Synonyms:(2S,3R)-3-hydroxy-3-[(S)-1-(4-methoxybenzyl)-5-oxopyrrolidin-2-yl]-3-phenyl-2-(triethylsilyloxy)propanal

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Chemical Property of (2S,3R)-3-hydroxy-3-[(S)-1-(4-methoxybenzyl)-5-oxopyrrolidin-2-yl]-3-phenyl-2-(triethylsilyloxy)propanal

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Technology Process of (2S,3R)-3-hydroxy-3-[(S)-1-(4-methoxybenzyl)-5-oxopyrrolidin-2-yl]-3-phenyl-2-(triethylsilyloxy)propanal

There total 1 articles about (2S,3R)-3-hydroxy-3-[(S)-1-(4-methoxybenzyl)-5-oxopyrrolidin-2-yl]-3-phenyl-2-(triethylsilyloxy)propanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1034170-16-5
(S)-5-[(1R,2R)-1-hydroxy-1-phenyl-2,3-bis(trimethylsilyloxy)propyl]-1-(4-methoxybenzyl)pyrrolidin-2-one

: 1034170-17-6
(2S,3R)-3-hydroxy-3-[(S)-1-(4-methoxybenzyl)-5-oxopyrrolidin-2-yl]-3-phenyl-2-(triethylsilyloxy)propanal

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -80 - -35 ℃; for 4.66667h; Inert atmosphere;
DOI:10.1002/ejoc.200800040

Reference yield: 72.0%

: 1034170-17-6
(2S,3R)-3-hydroxy-3-[(S)-1-(4-methoxybenzyl)-5-oxopyrrolidin-2-yl]-3-phenyl-2-(triethylsilyloxy)propanal

: 69739-34-0
t-butyldimethylsiyl triflate

: 1034170-18-7
(1R,2S,3R,4R,5S)-2-(tert-butyldimethylsilyloxy)-4-hydroxy-6-(4-methoxybenzyl)-4-phenyl-3-(triethylsilyloxy)-6-azabicyclo[3.2.1]octan-7-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 5h; optical yield given as %de; diastereoselective reaction;
DOI:10.1002/ejoc.200800040