(S)-6-fluoro-7-(2-fluoro-4-iodo-phenylamino)-8-(3-hydroxy-3-piperidin-2-yl-azetidine-1-carbonyl)-2,3-dihydro-1H-indolizin-5-one hydrochloride

Base Information

• Chemical Name: (S)-6-fluoro-7-(2-fluoro-4-iodo-phenylamino)-8-(3-hydroxy-3-piperidin-2-yl-azetidine-1-carbonyl)-2,3-dihydro-1H-indolizin-5-one hydrochloride
• CAS No.: 1193487-81-8
• Molecular Formula: C₂₃H₂₅F₂IN₄O₃*ClH
• Molecular Weight: 606.839

Synonyms:(S)-6-fluoro-7-(2-fluoro-4-iodo-phenylamino)-8-(3-hydroxy-3-piperidin-2-yl-azetidine-1-carbonyl)-2,3-dihydro-1H-indolizin-5-one hydrochloride

Chemical Property of (S)-6-fluoro-7-(2-fluoro-4-iodo-phenylamino)-8-(3-hydroxy-3-piperidin-2-yl-azetidine-1-carbonyl)-2,3-dihydro-1H-indolizin-5-one hydrochloride

Chemical Property:

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Technology Process of (S)-6-fluoro-7-(2-fluoro-4-iodo-phenylamino)-8-(3-hydroxy-3-piperidin-2-yl-azetidine-1-carbonyl)-2,3-dihydro-1H-indolizin-5-one hydrochloride

There total 1 articles about (S)-6-fluoro-7-(2-fluoro-4-iodo-phenylamino)-8-(3-hydroxy-3-piperidin-2-yl-azetidine-1-carbonyl)-2,3-dihydro-1H-indolizin-5-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-{1-[6-fluoro-7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carbonyl]-3-hydroxy-azetidin-3-yl}-piperidine-1-carboxylic acid tert-butyl ester (1193488-62-8) → (S)-6-fluoro-7-(2-fluoro-4-iodo-phenylamino)-8-(3-hydroxy-3-piperidin-2-yl-azetidine-1-carbonyl)-2,3-dihydro-1H-indolizin-5-one hydrochloride (1193487-81-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 1h;

upstream raw materials:

(S)-2-{1-[6-fluoro-7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carbonyl]-3-hydroxy-azetidin-3-yl}-piperidine-1-carboxylic acid tert-butyl ester

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