N-<3-(ethoxycarbonyl)-2-benzylidene-1-oxopropyl>glycine tert-butyl ester

Base Information

• Chemical Name: N-<3-(ethoxycarbonyl)-2-benzylidene-1-oxopropyl>glycine tert-butyl ester
• CAS No.: 87439-01-8
• Molecular Formula: C₁₉H₂₅NO₅
• Molecular Weight: 347.411
• Mol file: 87439-01-8.mol

Synonyms:N-<3-(ethoxycarbonyl)-2-benzylidene-1-oxopropyl>glycine tert-butyl ester

Chemical Property of N-<3-(ethoxycarbonyl)-2-benzylidene-1-oxopropyl>glycine tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-<3-(ethoxycarbonyl)-2-benzylidene-1-oxopropyl>glycine tert-butyl ester

There total 1 articles about N-<3-(ethoxycarbonyl)-2-benzylidene-1-oxopropyl>glycine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

Glycine tert-butyl ester (6456-74-2) + 3-(ethoxycarbonyl)-2-benzylidenepropanoic acid (87439-00-7) → N-<3-(ethoxycarbonyl)-2-benzylidene-1-oxopropyl>glycine tert-butyl ester (87439-01-8)

Guidance literature:

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; chloroform; Ambient temperature;

DOI:10.1021/jm00147a007

Reference yield: 83.0%

N-<3-(ethoxycarbonyl)-2-benzylidene-1-oxopropyl>glycine tert-butyl ester (87439-01-8) → N-(3-carboxy-2-benzylidene-1-oxopropyl)glycine tert-butyl ester (87439-02-9)

Guidance literature:

With sodium hydroxide; In ethanol; for 2h; Ambient temperature;

DOI:10.1021/jm00147a007

Reference yield:

N-<3-(ethoxycarbonyl)-2-benzylidene-1-oxopropyl>glycine tert-butyl ester (87439-01-8) → N-(N-hydroxy 3-carbamoyl 2-benzyl propanoyl)-glycine (92175-56-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 83 percent / 1 N aq. NaOH / ethanol / 2 h / Ambient temperature

2: 67 percent / Et₃N,1-hydroxybenzotriazol (HOBT), DCC / tetrahydrofuran; CHCl₃ / Ambient temperature

3: 69 percent / TFA / 1 h / Ambient temperature

4: 99 percent / H₂ / 10percent Pd on charcoal / methanol / 3 h / Ambient temperature

With sodium hydroxide; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; chloroform;

DOI:10.1021/jm00147a007

upstream raw materials:

Glycine tert-butyl ester

3-(ethoxycarbonyl)-2-benzylidenepropanoic acid

Downstream raw materials:

N-(3-carboxy-2-benzylidene-1-oxopropyl)glycine tert-butyl ester

N-(N-hydroxy 3-carbamoyl 2-benzyl propanoyl)-glycine

N-<3-<<(benzyloxy)amino>carbonyl>-2-benzylidene-1-oxopropyl>glycine

N-<3-<<(benzyloxy)amino>carbonyl>-2-benzylidene-1-oxopropyl>glycine tert-butyl ester