2-(2-(5'-bromo-2'-oxospiro[[1,3]dioxolane-2,3'-indoline]-1'-yl)acetamido)-N-hydroxy-3-phenylpropanamide

Base Information

Chemical Name:2-(2-(5'-bromo-2'-oxospiro[[1,3]dioxolane-2,3'-indoline]-1'-yl)acetamido)-N-hydroxy-3-phenylpropanamide
CAS No.:1430836-24-0
Molecular Formula:C₂₁H₂₀BrN₃O₆
Molecular Weight:490.31
Hs Code.:

Synonyms:2-(2-(5'-bromo-2'-oxospiro[[1,3]dioxolane-2,3'-indoline]-1'-yl)acetamido)-N-hydroxy-3-phenylpropanamide

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Chemical Property of 2-(2-(5'-bromo-2'-oxospiro[[1,3]dioxolane-2,3'-indoline]-1'-yl)acetamido)-N-hydroxy-3-phenylpropanamide

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Technology Process of 2-(2-(5'-bromo-2'-oxospiro[[1,3]dioxolane-2,3'-indoline]-1'-yl)acetamido)-N-hydroxy-3-phenylpropanamide

There total 8 articles about 2-(2-(5'-bromo-2'-oxospiro[[1,3]dioxolane-2,3'-indoline]-1'-yl)acetamido)-N-hydroxy-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.7%

: 1446416-14-3
C₂₂H₂₁BrN₂O₆

: 1430836-24-0
2-(2-(5'-bromo-2'-oxospiro[[1,3]dioxolane-2,3'-indoline]-1'-yl)acetamido)-N-hydroxy-3-phenylpropanamide

Guidance literature:: With hydroxylamine potassium salt; In methanol; for 1.5h;
DOI:10.1016/j.bmc.2012.06.024

Reference yield:

: 66475-83-0
N-(4-bromophenyl)-2-(hydroxyimino) acetamide

: 1430836-24-0
2-(2-(5'-bromo-2'-oxospiro[[1,3]dioxolane-2,3'-indoline]-1'-yl)acetamido)-N-hydroxy-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 7 steps

1: sulfuric acid / 0.5 h / 60 - 90 °C

2: toluene-4-sulfonic acid / toluene / 5 h / 130 °C

3: potassium carbonate; tetrabutylammomium bromide; potassium iodide / acetone / 6 h / 56 °C

4: potassium hydroxide / water; ethanol

5: 4-methyl-morpholine / tetrahydrofuran / 0.5 h / -15 °C

6: 4-methyl-morpholine / tetrahydrofuran / 13 h / -15 - 20 °C

7: hydroxylamine potassium salt / methanol / 1.5 h

With 4-methyl-morpholine; hydroxylamine potassium salt; sulfuric acid; tetrabutylammomium bromide; potassium carbonate; toluene-4-sulfonic acid; potassium iodide; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; water; acetone; toluene;
DOI:10.1016/j.bmc.2012.06.024

Reference yield:

: 331267-94-8
C₁₂H₁₀BrNO₅

: 1430836-24-0
2-(2-(5'-bromo-2'-oxospiro[[1,3]dioxolane-2,3'-indoline]-1'-yl)acetamido)-N-hydroxy-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 4-methyl-morpholine / tetrahydrofuran / 0.5 h / -15 °C

2: 4-methyl-morpholine / tetrahydrofuran / 13 h / -15 - 20 °C

3: hydroxylamine potassium salt / methanol / 1.5 h

With 4-methyl-morpholine; hydroxylamine potassium salt; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmc.2012.06.024