N₁-{4-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyrimidin-2-yl}-1-phenylpropane-1,3-diamine hydrochloride

Base Information

• Chemical Name: N₁-{4-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyrimidin-2-yl}-1-phenylpropane-1,3-diamine hydrochloride
• CAS No.: 1400669-86-4
• Molecular Formula: C₂₄H₂₉N₉*ClH
• Molecular Weight: 480.015

Synonyms:N₁-{4-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyrimidin-2-yl}-1-phenylpropane-1,3-diamine hydrochloride

Chemical Property of N₁-{4-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyrimidin-2-yl}-1-phenylpropane-1,3-diamine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₁-{4-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyrimidin-2-yl}-1-phenylpropane-1,3-diamine hydrochloride

There total 8 articles about N₁-{4-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyrimidin-2-yl}-1-phenylpropane-1,3-diamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3-{4-[8-(4-methyl-piperazin-1-yl)-imidazo[1,2-a]pyrazin-3-yl]-pyrimidin-2-ylamino}-3-phenyl-propyl)-carbamic acid tert-butyl ester (1400670-43-0) → N1-{4-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyrimidin-2-yl}-1-phenylpropane-1,3-diamine hydrochloride (1400669-86-4)

Guidance literature:

With hydrogenchloride; In ethanol; water; at 20 ℃; for 15h;

Reference yield:

Benzoylacetonitrile (614-16-4) → N1-{4-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyrimidin-2-yl}-1-phenylpropane-1,3-diamine hydrochloride (1400669-86-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 70 °C / Inert atmosphere

1.2: 0 °C

2.1: triethylamine / tetrahydrofuran / 0 - 20 °C

3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C

4.1: hydrazine hydrate / tetrahydrofuran; methanol / 6 h / 65 °C

5.1: 2 h / 140 °C

6.1: hydrogenchloride / ethanol; water / 15 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; hydrazine hydrate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; water;

Reference yield:

8-chloro-3-(2-methylsulfanyl-pyrimidin-4-yl)-imidazo[1,2-a]pyrazine (1400670-34-9) → N1-{4-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyrimidin-2-yl}-1-phenylpropane-1,3-diamine hydrochloride (1400669-86-4)

Guidance literature:

Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 15 h / Reflux

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 °C

3: 2 h / 140 °C

4: hydrogenchloride / ethanol; water / 15 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; water; isopropyl alcohol;

upstream raw materials:

Benzoylacetonitrile

(+/-)-N-(tert-butoxycarbonyl)-3-amino-1-phenylpropan-1-ol

(±)-tert-butyl N-(3-amino-3-phenyl-propyl)carbamate

3-(2-methanesulfonyl-pyrimidin-4-yl)-8-(4-methyl-piperazin-1-yl)-imidazo[1,2-a]pyrazine

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