Technology Process of (1β,3aβ,9aβ)-(+/-)-decahydro-1,8,8-trimethyl-6-(phenylmethoxy)-3aH-cyclopentacyclooctan-3a-ol
There total 48 articles about (1β,3aβ,9aβ)-(+/-)-decahydro-1,8,8-trimethyl-6-(phenylmethoxy)-3aH-cyclopentacyclooctan-3a-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 21 steps
1: NaBH4 / methanol / 0 °C
2: H2SO4 / diethyl ether
3: KO-t-Bu / tetrahydrofuran
4: DIBAH / toluene / -78 °C
5: NaH / tetrahydrofuran / 0 °C
6: 1.) O3; 2.) Me2S / 1.) CH2Cl2, -78 deg C; 2.) reflux
7: NaOH / methanol / Heating
8: DIBAH / diethyl ether / -100 °C
9: Et2Zn / toluene / 60 °C
10: PCC / CH2Cl2
11: tetrahydrofuran
12: 99 percent / BF3*Et2O / diethyl ether
13: tetrahydrofuran / 0.08 h / -30 °C
14: hexane / 4 h / 50 °C
15: diethyl ether / -78 °C
16: PCC / CH2Cl2
17: Me2S / diethyl ether
18: DIBAH / diethyl ether / -78 °C
19: 1.) KH / 1.) THF; 2.) THF
20: MCPBA / CHCl3
21: LiEt3BH / tetrahydrofuran
With
sodium hydroxide; sodium tetrahydroborate; dimethylsulfide; boron trifluoride diethyl etherate; potassium tert-butylate; diethylzinc; potassium hydride; sodium hydride; diisobutylaluminium hydride; lithium triethylborohydride; ozone; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate;
sulfuric acid;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; chloroform; toluene;
DOI:10.1021/ja00325a032
- Guidance literature:
-
Multi-step reaction with 21 steps
1: NaBH4 / methanol / 0 °C
2: H2SO4 / diethyl ether
3: KO-t-Bu / tetrahydrofuran
4: DIBAH / toluene / -78 °C
5: NaH / tetrahydrofuran / 0 °C
6: 1.) O3; 2.) Me2S / 1.) CH2Cl2, -78 deg C; 2.) reflux
7: NaOH / methanol / Heating
8: DIBAH / diethyl ether / -100 °C
9: Et2Zn / toluene / 60 °C
10: PCC / CH2Cl2
11: tetrahydrofuran
12: 99 percent / BF3*Et2O / diethyl ether
13: tetrahydrofuran / 0.08 h / -30 °C
14: hexane / 4 h / 50 °C
15: diethyl ether / -78 °C
16: PCC / CH2Cl2
17: Me2S / diethyl ether
18: DIBAH / diethyl ether / -78 °C
19: 1.) KH / 1.) THF; 2.) THF
20: MCPBA / CHCl3
21: LiEt3BH / tetrahydrofuran
With
sodium hydroxide; sodium tetrahydroborate; dimethylsulfide; boron trifluoride diethyl etherate; potassium tert-butylate; diethylzinc; potassium hydride; sodium hydride; diisobutylaluminium hydride; lithium triethylborohydride; ozone; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate;
sulfuric acid;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; chloroform; toluene;
DOI:10.1021/ja00325a032
- Guidance literature:
-
Multi-step reaction with 20 steps
1: H2SO4 / diethyl ether
2: KO-t-Bu / tetrahydrofuran
3: DIBAH / toluene / -78 °C
4: NaH / tetrahydrofuran / 0 °C
5: 1.) O3; 2.) Me2S / 1.) CH2Cl2, -78 deg C; 2.) reflux
6: NaOH / methanol / Heating
7: DIBAH / diethyl ether / -100 °C
8: Et2Zn / toluene / 60 °C
9: PCC / CH2Cl2
10: tetrahydrofuran
11: 99 percent / BF3*Et2O / diethyl ether
12: tetrahydrofuran / 0.08 h / -30 °C
13: hexane / 4 h / 50 °C
14: diethyl ether / -78 °C
15: PCC / CH2Cl2
16: Me2S / diethyl ether
17: DIBAH / diethyl ether / -78 °C
18: 1.) KH / 1.) THF; 2.) THF
19: MCPBA / CHCl3
20: LiEt3BH / tetrahydrofuran
With
sodium hydroxide; dimethylsulfide; boron trifluoride diethyl etherate; potassium tert-butylate; diethylzinc; potassium hydride; sodium hydride; diisobutylaluminium hydride; lithium triethylborohydride; ozone; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate;
sulfuric acid;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; chloroform; toluene;
DOI:10.1021/ja00325a032
