4-(2-bromo-4-fluorophenyl)-2-(4-(2-methoxy-2-oxoethyl)thiazole-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester

Base Information

• Chemical Name: 4-(2-bromo-4-fluorophenyl)-2-(4-(2-methoxy-2-oxoethyl)thiazole-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester
• CAS No.: 1571213-89-2
• Molecular Formula: C₂₀H₁₉BrFN₃O₄S
• Molecular Weight: 496.357

Synonyms:4-(2-bromo-4-fluorophenyl)-2-(4-(2-methoxy-2-oxoethyl)thiazole-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester

Chemical Property of 4-(2-bromo-4-fluorophenyl)-2-(4-(2-methoxy-2-oxoethyl)thiazole-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester

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Technology Process of 4-(2-bromo-4-fluorophenyl)-2-(4-(2-methoxy-2-oxoethyl)thiazole-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester

There total 2 articles about 4-(2-bromo-4-fluorophenyl)-2-(4-(2-methoxy-2-oxoethyl)thiazole-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2-bromo-4-fluorobenzaldehyde (59142-68-6) + 2-(2-methylthiazol-4-yl)acetic acid methyl ester hydrochloride + ethyl acetoacetate (141-97-9) → 4-(2-bromo-4-fluorophenyl)-2-(4-(2-methoxy-2-oxoethyl)thiazole-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester (1571213-89-2)

Guidance literature:

With sodium acetate; In methanol; at 80 ℃; for 12h; Inert atmosphere;

Reference yield: 50.0%

→ 4-(2-bromo-4-fluorophenyl)-2-(4-(2-methoxy-2-oxoethyl)thiazole-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester (1571213-89-2)

Guidance literature:

With sodium acetate; In ethanol; at 80 ℃; for 12h; Inert atmosphere;

Reference yield: 70.0%

4-(2-bromo-4-fluorophenyl)-2-(4-(2-methoxy-2-oxoethyl)thiazole-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester (1571213-89-2) → 4-(2-bromo-4-fluorophenyl)-6-(bromomethyl)-2-(4-(2-methoxy-2-oxoethyl)thiazole-2-yl)-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester (1571213-91-6)

Guidance literature:

With N-Bromosuccinimide; In tetrachloromethane; at 60 ℃; for 0.166667h; Inert atmosphere;

upstream raw materials:

2-bromo-4-fluorobenzaldehyde

ethyl acetoacetate

Downstream raw materials:

4-(2-bromo-4-fluorophenyl)-6-(bromomethyl)-2-(4-(2-methoxy-2-oxoethyl)thiazole-2-yl)-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester

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